Rhbg Rh family B glycoprotein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rhbgprovided by RGD
Official Full Name: Rh family B glycoproteinprovided by RGD
Primary source: RGD:727813
See related: EnsemblRapid:ENSRNOG00000019412 AllianceGenome:RGD:727813
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ammonium channel activity; ankyrin binding activity; and carbon dioxide transmembrane transporter activity. Predicted to be involved in ammonium homeostasis; ammonium transmembrane transport; and transepithelial ammonium transport. Located in basolateral plasma membrane. Orthologous to human RHBG (Rh family B glycoprotein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 170.2), Adrenal (RPKM 46.3) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (176002886..176015201, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (173704852..173717380, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (187610081..187622408, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In hypokalemia, Rhbg protein expression was decreased slightly in the kidney cortex and not detectably altered in the outer medulla.
Title: Effect of hypokalemia on renal expression of the ammonia transporter family members, Rh B Glycoprotein and Rh C Glycoprotein, in the rat kidney.
Expression of Rhbg and Rhcg parallels intercalated cell development and that immature Rhbg and Rhcg expression at birth contributes to incomplete ammonia excretion capacity.
Title: Expression of ammonia transporter family members, Rh B glycoprotein and Rh C glycoprotein, in the developing rat kidney.
Rhbg expression was unchanged in hypertrophy of both intercalated cells and principal cells in the cortical and outer medullary collecting duct
Title: Effect of reduced renal mass on renal ammonia transporter family, Rh C glycoprotein and Rh B glycoprotein, expression.
Rhbg protein and mRNA expression were unchanged in the cortex, outer and inner medulla, and no changes in Rhbg immunolabel were evident in these regions.
Title: Renal expression of the ammonia transporters, Rhbg and Rhcg, in response to chronic metabolic acidosis.
Review. Animal studies show Rhbg has a role in transmembrane NH3 or NH4+ transport in epithelial cells.
Title: Rh glycoproteins in epithelial cells: lessons from rat and mice studies.
Review. Rhbg is in distal nephron sites responsible for NH3 secretion and in perivenous hepatocyte basolateral plasma membrane. Cetabolic acidosis does not affect Rhbg, so it may be either an ammonia- sensor or mediate other roles.
Title: Expression of the non-erythroid Rh glycoproteins in mammalian tissues.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ammonium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ammonium channel activity	IEA Inferred from Electronic Annotation more info
enables ammonium channel activity	ISO Inferred from Sequence Orthology more info
enables ammonium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables ankyrin binding	ISO Inferred from Sequence Orthology more info
enables carbon dioxide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables carbon dioxide transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ammonium homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ammonium transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in ammonium transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in ammonium transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in ammonium transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
involved_in carbon dioxide transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transepithelial ammonium transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in spectrin-associated cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in spectrin-associated cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ammonium transporter Rh type B

Names: Rh type B glycoprotein; Rhesus blood group-associated B glycoprotein; rh family type B glycoprotein; rhesus blood group family type B glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_183054.1 → NP_898877.1 ammonium transporter Rh type B

See identical proteins and their annotated locations for NP_898877.1

Status: PROVISIONAL

Source sequence(s)

AY129072

UniProtKB/Swiss-Prot

Q68FT6, Q7TNP0

UniProtKB/TrEMBL

A6J659

Related

ENSRNOP00000026396.5, ENSRNOT00000026396.7

Conserved Domains (1) summary

cl03012
Location:58 → 403

Ammonium_transp; Ammonium Transporter Family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

176002886..176015201 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102306.2 → XP_038958234.1 ammonium transporter Rh type B isoform X2

UniProtKB/TrEMBL

A0A8I6GHX9

Conserved Domains (1) summary

cl03012
Location:58 → 368

Ammonium_transp; Ammonium Transporter Family
XM_063281834.1 → XP_063137904.1 ammonium transporter Rh type B isoform X4
XM_006232631.5 → XP_006232693.2 ammonium transporter Rh type B isoform X1

UniProtKB/Swiss-Prot

Q68FT6, Q7TNP0

UniProtKB/TrEMBL

A6J659
XM_006232633.5 → XP_006232695.2 ammonium transporter Rh type B isoform X3

UniProtKB/TrEMBL

A0A8I6GHX9