Psrc1 proline and serine rich coiled-coil 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Psrc1provided by RGD
Official Full Name: proline and serine rich coiled-coil 1provided by RGD
Primary source: RGD:1585037
See related: EnsemblRapid:ENSRNOG00000020013 AllianceGenome:RGD:1585037
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including mitotic metaphase chromosome alignment; positive regulation of macromolecule metabolic process; and regulation of microtubule cytoskeleton organization. Predicted to be located in several cellular components, including midbody; nucleoplasm; and spindle. Predicted to be active in microtubule cytoskeleton. Predicted to colocalize with spindle microtubule and spindle pole. Orthologous to human PSRC1 (proline and serine rich coiled-coil 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 21.3), Thymus (RPKM 12.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (198710427..198715001)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (196022361..196026874)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (211176437..211181078)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loc680254 regulates Schwann cell proliferation through Psrc1 and Ska1 as a microRNA sponge following sciatic nerve injury.
Title: Loc680254 regulates Schwann cell proliferation through Psrc1 and Ska1 as a microRNA sponge following sciatic nerve injury.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in microtubule bundle formation	IEA Inferred from Electronic Annotation more info
involved_in microtubule bundle formation	ISO Inferred from Sequence Orthology more info
involved_in mitotic metaphase chromosome alignment	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic metaphase chromosome alignment	IEA Inferred from Electronic Annotation more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic metaphase chromosome alignment	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microtubule polymerization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic spindle organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic spindle organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info
colocalizes_with spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle microtubule	IEA Inferred from Electronic Annotation more info
located_in spindle microtubule	ISO Inferred from Sequence Orthology more info
located_in spindle microtubule	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: proline/serine-rich coiled-coil protein 1

Names: proline/serine-rich coiled-coil 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044302.1 → NP_001037767.1 proline/serine-rich coiled-coil protein 1

See identical proteins and their annotated locations for NP_001037767.1

Status: PROVISIONAL

Source sequence(s)

BC105874

UniProtKB/Swiss-Prot

Q3KR66

UniProtKB/TrEMBL

A0A8I6ASD1, A6HV00

Related

ENSRNOP00000052733.1, ENSRNOT00000055880.4

Conserved Domains (1) summary

pfam15259
Location:10 → 124

GTSE1_N; G-2 and S-phase expressed 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

198710427..198715001

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063282592.1 → XP_063138662.1 proline/serine-rich coiled-coil protein 1 isoform X3

UniProtKB/Swiss-Prot

Q3KR66

UniProtKB/TrEMBL

A0A8I6ASD1, A6HV00
XM_006233179.4 → XP_006233241.1 proline/serine-rich coiled-coil protein 1 isoform X2

See identical proteins and their annotated locations for XP_006233241.1

UniProtKB/Swiss-Prot

Q3KR66

UniProtKB/TrEMBL

A0A8I6ASD1, A6HV00

Conserved Domains (1) summary

pfam15259
Location:10 → 124

GTSE1_N; G-2 and S-phase expressed 1
XM_006233176.5 → XP_006233238.1 proline/serine-rich coiled-coil protein 1 isoform X2

See identical proteins and their annotated locations for XP_006233238.1

UniProtKB/Swiss-Prot

Q3KR66

UniProtKB/TrEMBL

A0A8I6ASD1, A6HV00

Conserved Domains (1) summary

pfam15259
Location:10 → 124

GTSE1_N; G-2 and S-phase expressed 1
XM_006233177.4 → XP_006233239.2 proline/serine-rich coiled-coil protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6ASD1

Related

ENSRNOP00000111385.1, ENSRNOT00000161076.1

Conserved Domains (2) summary

pfam05109
Location:182 → 348

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam15259
Location:61 → 175

GTSE1_N; G-2 and S-phase expressed 1