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    Cntln centlein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 679640, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cntlnprovided by RGD
    Official Full Name
    centleinprovided by RGD
    Primary source
    RGD:1308101
    See related
    EnsemblRapid:ENSRNOG00000043151 AllianceGenome:RGD:1308101
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308101
    Summary
    Predicted to enable protein domain specific binding activity; protein kinase binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in centriole-centriole cohesion and protein localization to organelle. Predicted to act upstream of or within several processes, including regulation of protein localization; single fertilization; and spermatogenesis. Predicted to be located in cytosol; microtubule organizing center; and nucleoplasm. Predicted to be active in sperm head-tail coupling apparatus. Orthologous to human CNTLN (centlein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 68.4), Testes (RPKM 54.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cntln in Genome Data Viewer
    Location:
    5q31
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (104340801..104622491)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (99295865..99576402)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (103251986..103367088)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC103692399 Neighboring gene peptidylprolyl isomerase A, pseudogene 11 Neighboring gene SH3 domain containing GRB2 like 2, endophilin A1 Neighboring gene phosphoglycerate mutase 1, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of the novel centrosomal protein centlein. Makino K, et al. Biochem Biophys Res Commun, 2008 Feb 22. PMID 18086554
    2. Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion. Fang G, et al. J Cell Sci, 2014 Apr 15. PMID 24554434
    3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    4. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20276

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in centriole-centriole cohesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centriole-centriole cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in single fertilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within single fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm head-tail coupling apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in sperm head-tail coupling apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centlein
    Names
    centlein, centrosomal protein
    centrosomal protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114402.1 → NP_001107874.1  centlein

      Status: VALIDATED

      Source sequence(s)
      AB369315, BF394214, BU759324, CB699924, JAXUCZ010000005
      UniProtKB/Swiss-Prot
      A9ZSY0
      UniProtKB/TrEMBL
      A0A8I6ASB3
      Conserved Domains (1) summary
      TIGR02168
      Location:346 → 622
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      104340801..104622491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288373.1 → XP_063144443.1  centlein isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRW7

    2. XM_063288380.1 → XP_063144450.1  centlein isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZRW7
      Related
      ENSRNOP00000008757.7, ENSRNOT00000008757.8

    3. XM_063288375.1 → XP_063144445.1  centlein isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZRW7

    4. XM_063288374.1 → XP_063144444.1  centlein isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZRW7

    5. XM_063288376.1 → XP_063144446.1  centlein isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZRW7
      Related
      ENSRNOP00000097246.2, ENSRNOT00000098986.2

    6. XM_063288377.1 → XP_063144447.1  centlein isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZRW7

    7. XM_063288378.1 → XP_063144448.1  centlein isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZRW7

    8. XM_063288379.1 → XP_063144449.1  centlein isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZRW7
      Related
      ENSRNOP00000080911.2, ENSRNOT00000112551.2

    9. XM_063288381.1 → XP_063144451.1  centlein isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZRW7

    10. XM_063288382.1 → XP_063144452.1  centlein isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZRW7, A0A8I6ASX4
      Related
      ENSRNOP00000097573.1, ENSRNOT00000114509.2

    11. XM_063288383.1 → XP_063144453.1  centlein isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZRW7

    12. XM_063288384.1 → XP_063144454.1  centlein isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZRW7

    13. XM_063288387.1 → XP_063144457.1  centlein isoform X14

      UniProtKB/TrEMBL
      A0A8I5ZRW7

    14. XM_063288385.1 → XP_063144455.1  centlein isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZRW7
      Related
      ENSRNOP00000105526.1, ENSRNOT00000127933.1

    15. XM_063288388.1 → XP_063144458.1  centlein isoform X15

    16. XM_063288389.1 → XP_063144459.1  centlein isoform X16

    17. XM_063288390.1 → XP_063144460.1  centlein isoform X17

    18. XM_063288391.1 → XP_063144461.1  centlein isoform X18

    19. XM_039110761.1 → XP_038966689.1  centlein isoform X19

      UniProtKB/Swiss-Prot
      A9ZSY0
      Related
      ENSRNOP00000106717.1, ENSRNOT00000173143.1
      Conserved Domains (2) summary
      COG1196
      Location:2 → 704
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:381 → 731
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    20. XM_039110763.2 → XP_038966691.1  centlein isoform X20

      UniProtKB/Swiss-Prot
      A9ZSY0
      Conserved Domains (1) summary
      TIGR02168
      Location:319 → 669
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A9ZSY0.1 GenPept UniProtKB/Swiss-Prot:A9ZSY0

    Gene LinkOut

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