Eif2b1 eukaryotic translation initiation factor 2B subunit alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eif2b1provided by RGD
Official Full Name: eukaryotic translation initiation factor 2B subunit alphaprovided by RGD
Primary source: RGD:620819
See related: EnsemblRapid:ENSRNOG00000001039 AllianceGenome:RGD:620819
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: eIF-2a
Summary: Enables GDP binding activity; GTP binding activity; and translation initiation factor activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including negative regulation of guanyl-nucleotide exchange factor activity; response to amino acid starvation; and response to glucose. Part of eukaryotic translation initiation factor 2 complex and eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 1. Orthologous to human EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 129.1), Adrenal (RPKM 104.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q15

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (37686149..37694830)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (32025593..32033848)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (37444136..37452391)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GDP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
contributes_to guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
contributes_to guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
contributes_to translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IDA Inferred from Direct Assay more info	PubMed
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
contributes_to translation initiation factor activity	ISO Inferred from Sequence Orthology more info
contributes_to translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytoplasmic translational initiation	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic translational initiation	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic translational initiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in oligodendrocyte development	IEA Inferred from Electronic Annotation more info
involved_in oligodendrocyte development	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte development	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to amino acid starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to glucose	IDA Inferred from Direct Assay more info	PubMed
involved_in response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in response to peptide hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in translation	IDA Inferred from Direct Assay more info	PubMed
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in translational initiation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	ISO Inferred from Sequence Orthology more info
involved_in translational initiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 2B complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 2B complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 2B complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 2B complex	ISO Inferred from Sequence Orthology more info
part_of eukaryotic translation initiation factor 2B complex	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: translation initiation factor eIF2B subunit alpha

Names: GTP-exchange protein; eIF-2B GDP-GTP exchange factor subunit alpha; eIF-2Balpha; eIF2B GDP-GTP exchange factor subunit alpha; eukaryotic translation initiation factor 2B subunit 1 alpha; translation initiation factor eIF-2B subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172029.2 → NP_742026.1 translation initiation factor eIF2B subunit alpha

See identical proteins and their annotated locations for NP_742026.1

Status: VALIDATED

Source sequence(s)

BC081709

UniProtKB/Swiss-Prot

Q64270

UniProtKB/TrEMBL

A0A0G2JV57, A6J0Y3

Conserved Domains (2) summary

COG1184
Location:5 → 305

GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]

pfam01008
Location:17 → 293

IF-2B; Initiation factor 2 subunit family