Neurog3 neurogenin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Neurog3provided by RGD
Official Full Name: neurogenin 3provided by RGD
Primary source: RGD:631350
See related: EnsemblRapid:ENSRNOG00000024413 AllianceGenome:RGD:631350
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ngn3; Relax
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and double-stranded DNA binding activity. Involved in central nervous system development; positive regulation of neuron differentiation; and regulation of DNA-templated transcription. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in congenital malabsorptive diarrhea 4; glucose intolerance; and type 2 diabetes mellitus. Orthologous to human NEUROG3 (neurogenin 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (30622533..30624015)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (30079780..30081262)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (31761419..31762893)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of the developmental pathway neurogenin-3/microRNA-7a regulates cholangiocyte proliferation in response to injury.
Title: Activation of the developmental pathway neurogenin-3/microRNA-7a regulates cholangiocyte proliferation in response to injury.
The expression of transcription factor Ngn3 and pancreatic mesenchymal microenvironment are important and necessary to promote pancreatic progenitors differentiated to islet cells regardless of pancreatic development or islets regeneration.
Title: Short-reactivation of neurogenin-3 and mesenchymal microenvironment is require for β-cells differentiation during fetal pancreas development and islet regeneration.
Data show that Ngn3 and Pax4, a transcription factor that lies downstream of Ngn3 and plays an important role in beta-cell differentiation, were expressed in the alpha-cells of STZ-treated rats.
Title: Streptozotocin-induced expression of Ngn3 and Pax4 in neonatal rat pancreatic α-cells.
OVOL1, a downstream target of NGN3, may play an important role in regulating the balance between proliferation and differentiation of pancreatic cells
Title: OVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreas.
Ngn3 expressed together with Nkx6.1 or MafA induces AR42J-B13 cells to differentiate into insulin-producing cells, supporting the use of these cells as a model system for studying beta-cell differentiation in vitro.
Title: Combined expression of transcription factors induces AR42J-B13 cells to differentiate into insulin-producing cells.
Rat exocrine pancreas treated with epidermal growth factor and leukaemia inhibitory factor induced a transient expression of both Ngn3 and its upstream activator hepatocyte nuclear factor 6.
Title: Ngn3 expression during postnatal in vitro beta cell neogenesis induced by the JAK/STAT pathway.
glucose interferes with the pancreatic endocrine cells development by regulating the transition between Ngn3 and upstream NeuroD.
Title: Glucose is necessary for embryonic pancreatic endocrine cell differentiation.
role in regulating glial differentiation at a developmental stage prior to the segregation of the oligodendrocyte and astrocyte lineage
Title: Neurogenin3 participates in gliogenesis in the developing vertebrate spinal cord.

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General gene information

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Markers

PMC85623P2 (e-PCR)
- UniSTS:273479

UniSTS:462689 (e-PCR)
- UniSTS:462689

Neurog3 (e-PCR), detects polymorphism
- UniSTS:462689

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in forebrain development	IEP Inferred from Expression Pattern more info	PubMed
involved_in hindbrain development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in spinal cord development	IEP Inferred from Expression Pattern more info	PubMed
involved_in transdifferentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neurogenin-3

Names: transcriptional regulator, Relax

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.