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    Mphosph9 M-phase phosphoprotein 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288654, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mphosph9provided by RGD
    Official Full Name
    M-phase phosphoprotein 9provided by RGD
    Primary source
    RGD:1598368
    See related
    EnsemblRapid:ENSRNOG00000001074 AllianceGenome:RGD:1598368
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in negative regulation of cilium assembly. Predicted to be located in Golgi apparatus and centrosome. Predicted to be active in centriole. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human MPHOSPH9 (M-phase phosphoprotein 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 108.7), Testes (RPKM 95.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mphosph9 in Genome Data Viewer
    Location:
    12q15
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (37936442..38007053)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (32275449..32346097)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (37700282..37766487)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase 2 associated protein 1 Neighboring gene mitochondrial translation release factor in rescue Neighboring gene phosphatidylinositol transfer protein, membrane-associated 2 Neighboring gene uncharacterized LOC134481294 Neighboring gene ARF like GTPase 6 interacting protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base. Wang WJ, et al. Nat Cell Biol, 2013 Jun. PMID 23644468, Free PMC Article
    2. Identification of novel M phase phosphoproteins by expression cloning. Matsumoto-Taniura N, et al. Mol Biol Cell, 1996 Sep. PMID 8885239, Free PMC Article
    3. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. De Jager PL, et al. Lancet Neurol, 2009 Dec. PMID 19879194, Free PMC Article
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    M-phase phosphoprotein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170554.1 → NP_001164025.1  M-phase phosphoprotein 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I6A131
      Conserved Domains (1) summary
      COG1196
      Location:577 → 758
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      37936442..38007053
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271174.1 → XP_063127244.1  M-phase phosphoprotein 9 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A131
      Related
      ENSRNOP00000084896.2, ENSRNOT00000099626.2

    2. XM_039089226.2 → XP_038945154.1  M-phase phosphoprotein 9 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A131
      Conserved Domains (1) summary
      COG1196
      Location:574 → 759
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_039089233.2 → XP_038945161.1  M-phase phosphoprotein 9 isoform X3

      UniProtKB/TrEMBL
      D3Z9C8
      Conserved Domains (1) summary
      COG1196
      Location:531 → 712
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. XM_039089234.2 → XP_038945162.1  M-phase phosphoprotein 9 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A131
      Conserved Domains (1) summary
      COG1196
      Location:574 → 759
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. XM_039089231.2 → XP_038945159.1  M-phase phosphoprotein 9 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A131
      Conserved Domains (1) summary
      COG1196
      Location:574 → 759
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    6. XM_063271175.1 → XP_063127245.1  M-phase phosphoprotein 9 isoform X3

      UniProtKB/TrEMBL
      D3Z9C8

    7. XM_039089227.2 → XP_038945155.1  M-phase phosphoprotein 9 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A131
      Conserved Domains (1) summary
      COG1196
      Location:574 → 759
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    8. XM_039089229.2 → XP_038945157.1  M-phase phosphoprotein 9 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A131
      Conserved Domains (1) summary
      COG1196
      Location:574 → 759
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    9. XM_063271176.1 → XP_063127246.1  M-phase phosphoprotein 9 isoform X3

      UniProtKB/TrEMBL
      D3Z9C8

    10. XM_039089230.2 → XP_038945158.1  M-phase phosphoprotein 9 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A131
      Conserved Domains (1) summary
      COG1196
      Location:574 → 759
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. XR_005491618.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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