Rpl4 ribosomal protein L4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rpl4provided by RGD
Official Full Name: ribosomal protein L4provided by RGD
Primary source: RGD:619824
See related: EnsemblRapid:ENSRNOG00000009378 AllianceGenome:RGD:619824
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables 5S rRNA binding activity. Involved in brainstem development; cell differentiation; and positive regulation of axon extension. Located in A band. Part of cytosolic large ribosomal subunit. Is active in postsynaptic density. Orthologous to human RPL4 (ribosomal protein L4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 6482.9), Thymus (RPKM 5373.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (73566477..73571600)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (64671177..64676301)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (69121682..69126805)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

rpL4 may have certain roles in cell proliferation and differentiation during neurogenesis, but have no roles in 5AzC-induced apoptosis in the fetal brain
Title: Expression of ribosomal protein L4 (rpL4) during neurogenesis and 5-azacytidine (5AzC)-induced apoptotic process in the rat.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC350564P1 (e-PCR)
- UniSTS:273240

PMC18810P1 (e-PCR)
- UniSTS:271733

PMC140912P1 (e-PCR)
- UniSTS:270982

D14S106E (e-PCR)
- UniSTS:473010

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 5S rRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info
enables structural constituent of ribosome	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in brainstem development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in A band	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of cytosolic large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic large ribosomal subunit	IEA Inferred from Electronic Annotation more info
part_of cytosolic large ribosomal subunit	ISO Inferred from Sequence Orthology more info
located_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
part_of large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	EXP Inferred from Experiment more info	PubMed
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
located_in rough endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: large ribosomal subunit protein uL4

Names: 60S ribosomal protein L1; 60S ribosomal protein L4; L1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022510.1 → NP_071955.1 large ribosomal subunit protein uL4

See identical proteins and their annotated locations for NP_071955.1

Status: PROVISIONAL

Source sequence(s)

X82180

UniProtKB/Swiss-Prot

P50878

UniProtKB/TrEMBL

A0A8I6GAR6, Q6P3V9

Related

ENSRNOP00000013462.5, ENSRNOT00000013461.9

Conserved Domains (3) summary

PTZ00428
Location:2 → 350

PTZ00428; 60S ribosomal protein L4; Provisional

pfam14374
Location:275 → 348

Ribos_L4_asso_C; 60S ribosomal protein L4 C-terminal domain

cl00325
Location:10 → 265

Ribosomal_L4; Ribosomal protein L4/L1 family