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    Aktip AKT interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 14339, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aktipprovided by MGI
    Official Full Name
    AKT interacting proteinprovided by MGI
    Primary source
    MGI:MGI:3693832
    See related
    Ensembl:ENSMUSG00000031667 AllianceGenome:MGI:3693832
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ft; Fif; Ft1; Fts; AL023020
    Summary
    Predicted to enable NEDD8 transferase activity. Predicted to be involved in several processes, including early endosome to late endosome transport; protein localization to perinuclear region of cytoplasm; and protein neddylation. Predicted to act upstream of or within positive regulation of protein phosphorylation. Predicted to be located in plasma membrane. Predicted to be part of FHF complex and HOPS complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including ganglia; genitourinary system; hemolymphoid system gland; lung; and skin. Orthologous to human AKTIP (AKT interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 8.7), bladder adult (RPKM 7.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Aktip in Genome Data Viewer
    Location:
    8 C4; 8 44.25 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (91834267..91862122, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (91111781..91135494, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 9 Neighboring gene predicted gene 6658 Neighboring gene STARR-positive B cell enhancer ABC_E3792 Neighboring gene STARR-positive B cell enhancer ABC_E8848 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:93594488-93594671 Neighboring gene STARR-seq mESC enhancer starr_22297 Neighboring gene predicted gene, 39221 Neighboring gene predicted gene, 22428 Neighboring gene RB transcriptional corepressor like 2 Neighboring gene STARR-positive B cell enhancer mm9_chr8:93657981-93658282 Neighboring gene STARR-positive B cell enhancer mm9_chr8:93671652-93671953 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:93684510-93684619 Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene Neighboring gene predicted gene, 36243 Neighboring gene Rpgrip1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Programmed cell death is affected in the novel mouse mutant Fused toes (Ft). van der Hoeven F, et al. Development, 1994 Sep. PMID 7956835
    2. p53-Sensitive Epileptic Behavior and Inflammation in Ft1 Hypomorphic Mice. Burla R, et al. Front Genet, 2018. PMID 30546381, Free PMC Article
    3. Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits. La Torre M, et al. Aging Cell, 2018 Aug. PMID 29635765, Free PMC Article
    4. Insertional mutagenesis affecting programmed cell death leads to thymic hyperplasia and altered thymopoiesis. Volkmann A, et al. J Immunol, 1996 Jan 1. PMID 8598454
    5. The dominant mouse mutations fused toes (Ft) and oligosyndactylism (Os) are not allelic. Lesche R, et al. Mamm Genome, 1998 Jul. PMID 9657858

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Impact of diffused versus vasculature targeted DNA damage on the heart of mice depleted of telomeric factor Ft1.
      Title: Impact of diffused versus vasculature targeted DNA damage on the heart of mice depleted of telomeric factor Ft1.
    2. Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP.
      Title: Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP.
    3. Ft1 protein is required for telomere maintenance.
      Title: AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance.
    4. Primordial germ cell proliferation is impaired in Fused Toes mutant embryos.
      Title: Primordial germ cell proliferation is impaired in Fused Toes mutant embryos.
    5. Ft genes play an important role in dorsal-ventral patterning of the neural tube acting to define the extent of motor neuron generation
      Title: Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning.
    6. Owing to a deletion, six genes, including the entire IroquoisB (IrxB) gene cluster, are directly affected by the Ft mutation.
      Title: The mouse Fused toes (Ft) mutation is the result of a 1.6-Mb deletion including the entire Iroquois B gene cluster.
    7. Defects in brain patterning and head morphogenesis are caused by mutations in Fused toes gene.
      Title: Defects in brain patterning and head morphogenesis in the mouse mutant Fused toes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in early endosome to late endosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome to lysosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lysosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lysosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in postreplication repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K63-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of FHF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of FHF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of HOPS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of HOPS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AKT-interacting protein
    Names
    fused toes protein
    thymoma viral proto-oncogene 1 interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302266.1 → NP_001289195.1  AKT-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_001289195.1

      Status: VALIDATED

      Source sequence(s)
      AC122441, AK146459, BC034861, Z67963
      Consensus CDS
      CCDS22519.1
      UniProtKB/Swiss-Prot
      Q3TYE3, Q64362
      UniProtKB/TrEMBL
      Q05BP5
      Related
      ENSMUSP00000119277.3, ENSMUST00000125257.3
      Conserved Domains (1) summary
      smart00212
      Location:79 → 222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    2. NM_001302267.1 → NP_001289196.1  AKT-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_001289196.1

      Status: VALIDATED

      Source sequence(s)
      AC122441, AK146459, BC034861, CJ153808, Z67963
      Consensus CDS
      CCDS22519.1
      UniProtKB/Swiss-Prot
      Q3TYE3, Q64362
      UniProtKB/TrEMBL
      Q05BP5
      Related
      ENSMUSP00000112375.2, ENSMUST00000120213.9
      Conserved Domains (1) summary
      smart00212
      Location:79 → 222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    3. NM_001302268.1 → NP_001289197.1  AKT-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_001289197.1

      Status: VALIDATED

      Source sequence(s)
      AC122441, AK146459, AK158704, BC034861, Z67963
      Consensus CDS
      CCDS22519.1
      UniProtKB/Swiss-Prot
      Q3TYE3, Q64362
      UniProtKB/TrEMBL
      Q05BP5
      Related
      ENSMUSP00000105238.3, ENSMUST00000109609.9
      Conserved Domains (1) summary
      smart00212
      Location:79 → 222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    4. NM_001302337.1 → NP_001289266.1  AKT-interacting protein isoform 2

      See identical proteins and their annotated locations for NP_001289266.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate 3'-terminal exon compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC122441, AK017861, AK158704, BC034861, BM899517
      Consensus CDS
      CCDS85582.1
      UniProtKB/TrEMBL
      D3Z632, Q05BP5
      Related
      ENSMUSP00000113379.3, ENSMUST00000120426.9
      Conserved Domains (1) summary
      smart00212
      Location:79 → 222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    5. NM_001358934.1 → NP_001345863.1  AKT-interacting protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122441, Z67963
      UniProtKB/TrEMBL
      Q05BP5
      Conserved Domains (1) summary
      smart00212
      Location:79 → 222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    6. NM_001358935.1 → NP_001345864.1  AKT-interacting protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122441, Z67963
      UniProtKB/TrEMBL
      Q05BP5
      Conserved Domains (1) summary
      smart00212
      Location:79 → 222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    7. NM_001358936.1 → NP_001345865.1  AKT-interacting protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122441, Z67963
      UniProtKB/TrEMBL
      Q05BP5
      Conserved Domains (1) summary
      smart00212
      Location:79 → 222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    8. NM_001358937.1 → NP_001345866.1  AKT-interacting protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122441, Z67963
      Consensus CDS
      CCDS22519.1
      UniProtKB/Swiss-Prot
      Q3TYE3, Q64362
      UniProtKB/TrEMBL
      Q05BP5
      Conserved Domains (1) summary
      smart00212
      Location:79 → 222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    9. NM_001358938.1 → NP_001345867.1  AKT-interacting protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122441, Z67963
      Consensus CDS
      CCDS22519.1
      UniProtKB/Swiss-Prot
      Q3TYE3, Q64362
      UniProtKB/TrEMBL
      Q05BP5
      Conserved Domains (1) summary
      smart00212
      Location:79 → 222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    10. NM_010241.5 → NP_034371.1  AKT-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_034371.1

      Status: VALIDATED

      Source sequence(s)
      AC122441, AK146459, Z67963
      Consensus CDS
      CCDS22519.1
      UniProtKB/Swiss-Prot
      Q3TYE3, Q64362
      UniProtKB/TrEMBL
      Q05BP5
      Related
      ENSMUSP00000113769.2, ENSMUST00000120349.8
      Conserved Domains (1) summary
      smart00212
      Location:79 → 222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      91834267..91862122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530673.5 → XP_006530736.1  AKT-interacting protein isoform X5

      See identical proteins and their annotated locations for XP_006530736.1

      UniProtKB/TrEMBL
      D3Z632, Q05BP5
      Conserved Domains (1) summary
      smart00212
      Location:79 → 222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    2. XM_030243297.2 → XP_030099157.1  AKT-interacting protein isoform X6

      UniProtKB/TrEMBL
      Q05BP5
      Conserved Domains (1) summary
      smart00212
      Location:74 → 217
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    3. XM_030243295.2 → XP_030099155.1  AKT-interacting protein isoform X5

      UniProtKB/TrEMBL
      D3Z632, Q05BP5
      Conserved Domains (1) summary
      smart00212
      Location:79 → 222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    4. XM_030243294.2 → XP_030099154.1  AKT-interacting protein isoform X5

      UniProtKB/TrEMBL
      D3Z632, Q05BP5
      Conserved Domains (1) summary
      smart00212
      Location:79 → 222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    5. XM_030243296.2 → XP_030099156.1  AKT-interacting protein isoform X5

      UniProtKB/TrEMBL
      D3Z632, Q05BP5
      Conserved Domains (1) summary
      smart00212
      Location:79 → 222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    6. XM_030243291.2 → XP_030099151.1  AKT-interacting protein isoform X3

      UniProtKB/TrEMBL
      Q05BP5
      Conserved Domains (1) summary
      smart00212
      Location:74 → 217
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    7. XM_017312574.3 → XP_017168063.1  AKT-interacting protein isoform X4

      UniProtKB/TrEMBL
      Q05BP5
      Conserved Domains (1) summary
      smart00212
      Location:74 → 217
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    8. XM_011248307.4 → XP_011246609.1  AKT-interacting protein isoform X3

      UniProtKB/TrEMBL
      Q05BP5
      Conserved Domains (1) summary
      smart00212
      Location:74 → 217
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    9. XM_030243289.2 → XP_030099149.1  AKT-interacting protein isoform X2

      UniProtKB/Swiss-Prot
      Q3TYE3, Q64362
      UniProtKB/TrEMBL
      Q05BP5
      Conserved Domains (1) summary
      smart00212
      Location:79 → 222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    10. XM_011248304.4 → XP_011246606.1  AKT-interacting protein isoform X1

      See identical proteins and their annotated locations for XP_011246606.1

      UniProtKB/TrEMBL
      Q05BP5
      Conserved Domains (1) summary
      smart00212
      Location:79 → 222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    11. XM_030243293.2 → XP_030099153.1  AKT-interacting protein isoform X4

      UniProtKB/TrEMBL
      Q05BP5
      Conserved Domains (1) summary
      smart00212
      Location:74 → 217
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    12. XM_011248303.4 → XP_011246605.1  AKT-interacting protein isoform X1

      See identical proteins and their annotated locations for XP_011246605.1

      UniProtKB/TrEMBL
      Q05BP5
      Conserved Domains (1) summary
      smart00212
      Location:79 → 222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    13. XM_030243292.2 → XP_030099152.1  AKT-interacting protein isoform X4

      UniProtKB/TrEMBL
      Q05BP5
      Conserved Domains (1) summary
      smart00212
      Location:74 → 217
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    14. XM_036153758.1 → XP_036009651.1  AKT-interacting protein isoform X4

      UniProtKB/TrEMBL
      Q05BP5
      Conserved Domains (1) summary
      smart00212
      Location:74 → 217
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    15. XM_011248306.4 → XP_011246608.1  AKT-interacting protein isoform X1

      See identical proteins and their annotated locations for XP_011246608.1

      UniProtKB/TrEMBL
      Q05BP5
      Conserved Domains (1) summary
      smart00212
      Location:79 → 222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    16. XM_030243290.1 → XP_030099150.1  AKT-interacting protein isoform X2

      UniProtKB/Swiss-Prot
      Q3TYE3, Q64362
      UniProtKB/TrEMBL
      Q05BP5
      Conserved Domains (1) summary
      smart00212
      Location:79 → 222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    17. XM_017312571.1 → XP_017168060.1  AKT-interacting protein isoform X1

      UniProtKB/TrEMBL
      Q05BP5
      Conserved Domains (1) summary
      smart00212
      Location:79 → 222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64362.1 GenPept UniProtKB/Swiss-Prot:Q64362

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