Retnla resistin like alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Retnlaprovided by MGI
Official Full Name: resistin like alphaprovided by MGI
Primary source: MGI:MGI:1888504
See related: Ensembl:ENSMUSG00000061100 AllianceGenome:MGI:1888504
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HIMF; Xcp2; Fizz1; RELMa; Fizz-1; RELMalpha; RELM-alpha; 1810019L16Rik
Summary: Predicted to enable hormone activity. Acts upstream of or within response to nematode and response to selenium ion. Located in extracellular region. Is expressed in several structures, including brain; gut; mammary gland; respiratory system; and white fat. Orthologous to human RETNLB (resistin like beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in mammary gland adult (RPKM 357.7), subcutaneous fat pad adult (RPKM 170.8) and 3 other tissues See more
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Genomic context

Location:: 16 B5; 16 30.75 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (48662972..48664824)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (48842609..48844461)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Choline metabolism underpins macrophage IL-4 polarization and RELMalpha up-regulation in helminth infection.
Title: Choline metabolism underpins macrophage IL-4 polarization and RELMα up-regulation in helminth infection.
Macrophage-Regulatory T Cell Interactions Promote Type 2 Immune Homeostasis Through Resistin-Like Molecule alpha.
Title: Macrophage-Regulatory T Cell Interactions Promote Type 2 Immune Homeostasis Through Resistin-Like Molecule α.
HIMF deletion ameliorates acute myocardial ischemic injury by promoting macrophage transformation to reparative subtype.
Title: HIMF deletion ameliorates acute myocardial ischemic injury by promoting macrophage transformation to reparative subtype.
In situ evidence of collagen V and signaling pathway of found inflammatory zone 1 (FIZZ1) is associated with silicotic granuloma in lung mice.
Title: In situ evidence of collagen V and signaling pathway of found inflammatory zone 1 (FIZZ1) is associated with silicotic granuloma in lung mice.
RELMalpha is Induced in Airway Epithelial Cells by Oncostatin M Without Requirement of STAT6 or IL-6 in Mouse Lungs In Vivo.
Title: RELMα is Induced in Airway Epithelial Cells by Oncostatin M Without Requirement of STAT6 or IL-6 in Mouse Lungs In Vivo.
The RELMalpha/hresistin-induced macrophage-specific HMGB1/RAGE expression and facilitated HMGB1 nucleus-to-cytoplasm translocation and extracellular secretion.
Title: RELMα Licenses Macrophages for Damage-Associated Molecular Pattern Activation to Instigate Pulmonary Vascular Remodeling.
RELMalpha-expressing macrophages were essential to prevent fatal lung damage during primary N. brasiliensis infection and to provide protective immunity against migrating parasites during secondary challenge.
Title: RELMα-expressing macrophages protect against fatal lung damage and reduce parasite burden during helminth infection.
In HIMF-induced PH, HMGB1-RAGE signaling is pivotal for mediating EC-smooth muscle cell crosstalk. The humanized mouse data further support clinical implications for the HIMF/HMGB1 signaling axis and indicate that hResistin and its downstream pathway may constitute targets for the development of novel anti-PH therapeutics in humans.
Title: HIMF (Hypoxia-Induced Mitogenic Factor) Signaling Mediates the HMGB1 (High Mobility Group Box 1)-Dependent Endothelial and Smooth Muscle Cell Crosstalk in Pulmonary Hypertension.
Here, the authors show that resistin-like molecule alpha (RELMalpha), a small secreted cysteine-rich protein, is expressed by epidermal keratinocytes and sebocytes and serves as an antimicrobial protein that is required for vitamin-A-dependent resistance to skin infection.
Title: Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the Skin.
B cells produced high levels of the tissue-protective protein, Resistin-like molecule alpha (RELMalpha), which then downregulated IL-17A expression.
Title: B Cells Produce the Tissue-Protective Protein RELMα during Helminth Infection, which Inhibits IL-17 Expression and Limits Emphysema.

Submit: New GeneRIF Correction See all GeneRIFs (58)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (5) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within response to nematode	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to selenium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: resistin-like alpha

Names: cysteine-rich secreted protein A12-gamma; cysteine-rich secreted protein FIZZ1; found in inflammatory zone 1; hypoxia-induced mitogenic factor; parasite-induced macrophage novel gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020509.4 → NP_065255.3 resistin-like alpha precursor

Status: VALIDATED

Source sequence(s)

AC154529

Consensus CDS

CCDS49864.2

UniProtKB/Swiss-Prot

Q9D8Y4, Q9EP95

UniProtKB/TrEMBL

Q78ZN4, Q8JZM3

Related

ENSMUSP00000159097.2, ENSMUST00000238847.2

Conserved Domains (1) summary

pfam06954
Location:23 → 110

Resistin