U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Eml2 EMAP like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192360, updated on 27-Nov-2024

    Summary

    Official Symbol
    Eml2provided by RGD
    Official Full Name
    EMAP like 2provided by RGD
    Primary source
    RGD:621066
    See related
    EnsemblRapid:ENSRNOG00000030127 AllianceGenome:RGD:621066
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Emap; Eml1; Emap-2
    Summary
    Enables ionotropic glutamate receptor binding activity. Predicted to be involved in microtubule cytoskeleton organization; negative regulation of microtubule polymerization; and regulation of microtubule nucleation. Predicted to be located in cytoplasm; membrane; and microtubule. Predicted to colocalize with mitotic spindle. Orthologous to human EML2 (EMAP like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 167.7), Lung (RPKM 48.1) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Eml2 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (87955924..87987366)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (78827595..78859342)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (80087684..80118784)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glutaminyl-peptide cyclotransferase-like Neighboring gene small nuclear ribonucleoprotein D2 polypeptide Neighboring gene gastric inhibitory polypeptide receptor Neighboring gene microRNA 330 Neighboring gene G protein-coupled receptor 4 Neighboring gene outer mitochondrial membrane lipid metabolism regulator OPA3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ionotropic glutamate receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of microtubule polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of microtubule polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of microtubule nucleation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of microtubule nucleation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    echinoderm microtubule-associated protein-like 2
    Names
    echinoderm microtubule associated protein like 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414650.1NP_001401579.1  echinoderm microtubule-associated protein-like 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q6P6T4, Q8VIM8
      Related
      ENSRNOP00000075212.2, ENSRNOT00000078336.3
    2. NM_138921.3NP_620276.3  echinoderm microtubule-associated protein-like 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8L2QPN8
      Related
      ENSRNOP00000046691.5, ENSRNOT00000041215.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      87955924..87987366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093491.2XP_038949419.1  echinoderm microtubule-associated protein-like 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6B6G9
      Conserved Domains (5) summary
      COG2319
      Location:267688
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:401438
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:210282
      HELP; HELP motif
      cd21948
      Location:59106
      TD_EMAP2; trimerization domain of echinoderm microtubule-associated protein-like 2
      cl29593
      Location:564838
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_039093638.2XP_038949566.1  echinoderm microtubule-associated protein-like 2 isoform X4

      UniProtKB/TrEMBL
      A6J8K6
      Conserved Domains (4) summary
      sd00039
      Location:301349
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:211283
      HELP; HELP motif
      cd21948
      Location:59106
      TD_EMAP2; trimerization domain of echinoderm microtubule-associated protein-like 2
      cl29593
      Location:291513
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_039093526.2XP_038949454.1  echinoderm microtubule-associated protein-like 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6B6G9
      Related
      ENSRNOP00000096394.2, ENSRNOT00000113449.2
      Conserved Domains (5) summary
      COG2319
      Location:222643
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:356393
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:165237
      HELP; HELP motif
      cd21948
      Location:1360
      TD_EMAP2; trimerization domain of echinoderm microtubule-associated protein-like 2
      cl29593
      Location:519793
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. XM_039093551.2XP_038949479.1  echinoderm microtubule-associated protein-like 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AQQ2, A0A8I6B6G9
      Related
      ENSRNOP00000097902.1, ENSRNOT00000107022.2
      Conserved Domains (5) summary
      COG2319
      Location:221642
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:355392
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:164236
      HELP; HELP motif
      cd21948
      Location:1360
      TD_EMAP2; trimerization domain of echinoderm microtubule-associated protein-like 2
      cl29593
      Location:518792
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_010061162.1 RNA Sequence