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    Ceacam6 CEA cell adhesion molecule 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100125369, updated on 9-Dec-2024

    Summary

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    Symbol
    Ceacam6provided by RGD
    Full Name
    CEA cell adhesion molecule 6provided by RGD
    Primary source
    RGD:1642421
    See related
    EnsemblRapid:ENSRNOG00000030331 AllianceGenome:RGD:1642421
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity; protein heterodimerization activity; and protein tyrosine kinase binding activity. Predicted to be involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and positive regulation of cell adhesion. Predicted to be located in apical plasma membrane and extracellular space. Predicted to be active in cell surface and plasma membrane. Orthologous to several human genes including CEACAM6 (CEA cell adhesion molecule 6); PSG4 (pregnancy specific beta-1-glycoprotein 4); and PSG6 (pregnancy specific beta-1-glycoprotein 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 198.9) See more
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    Genomic context

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    See Ceacam6 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (89544415..89562552)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (80416531..80434668)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (81683500..81701230)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene CEA cell adhesion molecule 4 Neighboring gene uncharacterized LOC108349556 Neighboring gene Ly6/Plaur domain containing 4 Neighboring gene DMRT-like family C2 Neighboring gene ribosomal protein S19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Testis-specific cell adhesion molecule, CEACAM6-L, forms homophilic interaction at the cell adhesion site in vitro. Kurio H, et al. Zoolog Sci, 2012 Nov. PMID 23106565
    2. Intron retention generates a novel isoform of CEACAM6 that may act as an adhesion molecule in the ectoplasmic specialization structures between spermatids and sertoli cells in rat testis. Kurio H, et al. Biol Reprod, 2008 Dec. PMID 18685128
    3. Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen). Blumenthal RD, et al. Cancer Res, 2005 Oct 1. PMID 16204051
    4. MicroRNA-29a suppresses the growth, migration, and invasion of lung adenocarcinoma cells by targeting carcinoembryonic antigen-related cell adhesion molecule 6. Han HS, et al. FEBS Lett, 2014 Oct 16. PMID 25171863
    5. Identification and comparison of residues critical for cell-adhesion activities of two neutrophil CD66 antigens, CEACAM6 and CEACAM8. Kuroki M, et al. J Leukoc Biol, 2001 Oct. PMID 11590190

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that CEACAM6-L expressed in both germ cells and Sertoli cells forms homophilic trans-tetra complexes between these cells in the seminiferous epithelium.
      Title: Testis-specific cell adhesion molecule, CEACAM6-L, forms homophilic interaction at the cell adhesion site in vitro.
    2. CEACAM6-L might be a novel adhesion molecule constructing the apical ectoplasmic specialization in testis
      Title: Intron retention generates a novel isoform of CEACAM6 that may act as an adhesion molecule in the ectoplasmic specialization structures between spermatids and sertoli cells in rat testis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Other Names

    • carcinoembryonic antigen-related cell adhesion molecule 1-like
    • carcinoembryonic antigen-related cell adhesion molecule 6
    • carcinoembryonic antigen-related cell adhesion molecule 6-like

    Clone Names

    • MGC93832

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_045097.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BC078962
      Related
      ENSRNOT00000057600.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      89544415..89562552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001103358.1: Suppressed sequence

      Description
      NM_001103358.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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