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    Leng8 leukocyte receptor cluster member 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361506, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Leng8provided by RGD
    Official Full Name
    leukocyte receptor cluster member 8provided by RGD
    Primary source
    RGD:1306180
    See related
    EnsemblRapid:ENSRNOG00000018642 AllianceGenome:RGD:1306180
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be active in nucleus. Orthologous to human LENG8 (leukocyte receptor cluster member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 215.6), Thymus (RPKM 207.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Leng8 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (79113038..79124868, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (70040785..70052662, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (73722088..73734459, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin like receptor A5 Neighboring gene ornithine decarboxylase 1, pseudogene 7 Neighboring gene CDC42 effector protein 5 Neighboring gene leukocyte receptor cluster member 9 Neighboring gene tweety family member 1 Neighboring gene leukocyte-associated immunoglobulin-like receptor 1 Neighboring gene uncharacterized LOC134482886

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112858

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leukocyte receptor cluster member 8
    Names
    leukocyte receptor cluster (LRC) member 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037790.4 → NP_001032879.2  leukocyte receptor cluster member 8

      See identical proteins and their annotated locations for NP_001032879.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6KNJ5, D3ZX52
      Related
      ENSRNOP00000025338.5, ENSRNOT00000025338.9
      Conserved Domains (2) summary
      pfam03399
      Location:569 → 754
      SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
      pfam12346
      Location:464 → 550
      HJURP_mid; Holliday junction recognition protein-associated repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      79113038..79124868 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266341.1 → XP_063122411.1  leukocyte receptor cluster member 8 isoform X7

    2. XM_063266337.1 → XP_063122407.1  leukocyte receptor cluster member 8 isoform X4

      Related
      ENSRNOP00000101769.1, ENSRNOT00000148159.1

    3. XM_063266340.1 → XP_063122410.1  leukocyte receptor cluster member 8 isoform X6

    4. XM_006228220.4 → XP_006228282.1  leukocyte receptor cluster member 8 isoform X2

      Conserved Domains (3) summary
      pfam03399
      Location:549 → 734
      SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
      pfam09849
      Location:119 → 256
      DUF2076; Uncharacterized protein conserved in bacteria (DUF2076)
      pfam12346
      Location:444 → 530
      HJURP_mid; Holliday junction recognition protein-associated repeat

    5. XM_008758948.4 → XP_008757170.1  leukocyte receptor cluster member 8 isoform X5

      See identical proteins and their annotated locations for XP_008757170.1

      UniProtKB/TrEMBL
      A6KNJ4
      Conserved Domains (2) summary
      pfam03399
      Location:569 → 764
      SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
      pfam12346
      Location:464 → 550
      HJURP_mid; Holliday junction recognition protein-associated repeat

    6. XM_008758946.4 → XP_008757168.1  leukocyte receptor cluster member 8 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K0W4
      Related
      ENSRNOP00000071606.1, ENSRNOT00000077964.3
      Conserved Domains (2) summary
      pfam03399
      Location:586 → 781
      SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
      pfam12346
      Location:481 → 567
      HJURP_mid; Holliday junction recognition protein-associated repeat

    7. XM_006228218.4 → XP_006228280.1  leukocyte receptor cluster member 8 isoform X1

      See identical proteins and their annotated locations for XP_006228280.1

      UniProtKB/TrEMBL
      A0A8I6GKE0
      Related
      ENSRNOP00000093659.1, ENSRNOT00000111838.2
      Conserved Domains (2) summary
      pfam03399
      Location:586 → 771
      SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
      pfam12346
      Location:481 → 567
      HJURP_mid; Holliday junction recognition protein-associated repeat

    8. XM_063266339.1 → XP_063122409.1  leukocyte receptor cluster member 8 isoform X5

      UniProtKB/TrEMBL
      A6KNJ4

    9. XM_063266336.1 → XP_063122406.1  leukocyte receptor cluster member 8 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K0W4

    10. XM_006228219.5 → XP_006228281.1  leukocyte receptor cluster member 8 isoform X1

      See identical proteins and their annotated locations for XP_006228281.1

      UniProtKB/TrEMBL
      A0A8I6GKE0
      Conserved Domains (2) summary
      pfam03399
      Location:586 → 771
      SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
      pfam12346
      Location:481 → 567
      HJURP_mid; Holliday junction recognition protein-associated repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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