Tomm40 translocase of outer mitochondrial membrane 40 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tomm40provided by RGD
Official Full Name: translocase of outer mitochondrial membrane 40provided by RGD
Primary source: RGD:1303022
See related: EnsemblRapid:ENSRNOG00000018556 AllianceGenome:RGD:1303022
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: OM38; TOM40
Summary: Enables monoatomic cation channel activity; preprotein binding activity; and protein transmembrane transporter activity. Involved in positive regulation of apoptotic process; protein insertion into mitochondrial membrane; and protein targeting to mitochondrion. Located in mitochondrial outer membrane. Part of mitochondrial outer membrane translocase complex. Human ortholog(s) of this gene implicated in cerebral infarction. Orthologous to human TOMM40 (translocase of outer mitochondrial membrane 40). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 185.9), Kidney (RPKM 160.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (88486745..88498833, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (79358781..79370882, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (80617749..80630253, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the role of miR-126 and TOMM40 in heat stressed cardiomyocytes, is reported.
Title: Epigenetic upregulation of miR-126 induced by heat stress contributes to apoptosis of rat cardiomyocytes by promoting Tomm40 transcription.
interaction between Tom40 and presequence peptides is mainly electrostatic in nature
Title: Structural characterisation of a full-length mitochondrial outer membrane TOM40 preprotein translocase: implications for its interaction with presequence peptides.
Import of Tom40 did not differ between young and aged animals, but its subsequent assembly into the final approximately 380 kDa complex was higher in mitochondria from aged compared with young animals. Chornic contractile activity altered Tom40 levels.
Title: Biogenesis of the mitochondrial Tom40 channel in skeletal muscle from aged animals and its adaptability to chronic contractile activity.
Tom40B is a functional component of mitochondrial outer membrane translocase
Title: Identification and characterization of a new tom40 isoform, a central component of mitochondrial outer membrane translocase.
C-terminal half of rTOM40 constitutes the preprotein recognition domain with an enriched beta-structure
Title: Membrane-embedded C-terminal segment of rat mitochondrial TOM40 constitutes protein-conducting pore with enriched beta-structure.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables porin activity	IEA Inferred from Electronic Annotation more info
enables preprotein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables protein transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into mitochondrial matrix	IEA Inferred from Electronic Annotation more info
involved_in protein insertion into mitochondrial membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to mitochondrion	IDA Inferred from Direct Assay more info	PubMed
involved_in protein targeting to mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondria-associated endoplasmic reticulum membrane contact site	IEA Inferred from Electronic Annotation more info
located_in mitochondria-associated endoplasmic reticulum membrane contact site	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
part_of mitochondrial outer membrane translocase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial outer membrane translocase complex	IDA Inferred from Direct Assay more info	PubMed
part_of mitochondrial outer membrane translocase complex	IEA Inferred from Electronic Annotation more info
part_of mitochondrial outer membrane translocase complex	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
NOT located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of pore complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitochondrial import receptor subunit TOM40 homolog

Names: mitochondrial outer membrane protein of 38 kDa; outer membrane protein 38 kDa; translocase of outer membrane 40 kDa subunit homolog; translocase of outer mitochondrial membrane 40 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212520.2 → NP_997685.2 mitochondrial import receptor subunit TOM40 homolog

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q75Q40

UniProtKB/TrEMBL

A6J8T5, G3V8F5

Related

ENSRNOP00000025281.1, ENSRNOT00000025281.4