Klhl20 kelch-like family member 20 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klhl20provided by RGD
Official Full Name: kelch-like family member 20provided by RGD
Primary source: RGD:1309490
See related: EnsemblRapid:ENSRNOG00000002875 AllianceGenome:RGD:1309490
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309490
Summary: Predicted to enable type II interferon binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including Golgi to endosome transport; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K33-linked ubiquitination. Predicted to be located in Golgi apparatus and cytosol. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in PML body and trans-Golgi network. Orthologous to human KLHL20 (kelch like family member 20). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 65.7), Heart (RPKM 55.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q22

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (75896802..75941724, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (73363451..73408293, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (78912361..78957226, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables type II interferon binding	IEA Inferred from Electronic Annotation more info
enables type II interferon binding	ISO Inferred from Sequence Orthology more info
enables type II interferon binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
contributes_to ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
contributes_to ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Golgi to endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi to endosome transport	IEA Inferred from Electronic Annotation more info
involved_in Golgi to endosome transport	ISO Inferred from Sequence Orthology more info
involved_in Golgi to endosome transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K33-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K33-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K33-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul3-RING ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of Cul3-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul3-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in PML body	IBA Inferred from Biological aspect of Ancestor more info
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in PML body	ISS Inferred from Sequence or Structural Similarity more info
located_in axon	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: kelch-like protein 20

Names: kelch-like 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107192.2 → NP_001100662.1 kelch-like protein 20

See identical proteins and their annotated locations for NP_001100662.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

D3Z8N4

Related

ENSRNOP00000068007.3, ENSRNOT00000076954.4

Conserved Domains (3) summary

PHA03098
Location:63 → 586

PHA03098; kelch-like protein; Provisional

sd00038
Location:355 → 399

Kelch; KELCH repeat [structural motif]

cd18249
Location:45 → 172

BTB_POZ_KLHL20_KLEIP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

75896802..75941724 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008769649.4 → XP_008767871.1 kelch-like protein 20 isoform X1

UniProtKB/TrEMBL

A0A8L2QYR5

Related

ENSRNOP00000003851.6, ENSRNOT00000003851.7

Conserved Domains (6) summary

smart00612
Location:439 → 484

Kelch; Kelch domain

PHA03098
Location:87 → 610

PHA03098; kelch-like protein; Provisional

sd00038
Location:379 → 423

Kelch; KELCH repeat [structural motif]

pfam00651
Location:83 → 186

BTB; BTB/POZ domain

pfam01344
Location:567 → 612

Kelch_1; Kelch motif

pfam07707
Location:194 → 295

BACK; BTB And C-terminal Kelch