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    Pold2 DNA polymerase delta 2, accessory subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289758, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pold2provided by RGD
    Official Full Name
    DNA polymerase delta 2, accessory subunitprovided by RGD
    Primary source
    RGD:1304954
    See related
    EnsemblRapid:ENSRNOG00000014098 AllianceGenome:RGD:1304954
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity. Involved in DNA-templated DNA replication. Part of delta DNA polymerase complex. Orthologous to human POLD2 (DNA polymerase delta 2, accessory subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 74.8), Heart (RPKM 70.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pold2 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (84962933..84969148, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (80748971..80755188, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (86111416..86117578, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene DNA polymerase mu Neighboring gene AE binding protein 1 Neighboring gene uncharacterized LOC108352788 Neighboring gene myosin light chain 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A mutation detected in DNA polymerase delta cDNA from Novikoff hepatoma cells correlates with abnormal catalytic properties of the enzyme. Popanda O, et al. J Cancer Res Clin Oncol, 1999 Nov. PMID 10541966
    2. A novel PDIP1-related protein, KCTD10, that interacts with proliferating cell nuclear antigen and DNA polymerase delta. Zhou J, et al. Biochim Biophys Acta, 2005 Jul 10. PMID 15982757
    3. DNA polymerases and repair synthesis in NER in human cells. Lehmann AR. DNA Repair (Amst), 2011 Jul 15. PMID 21601536
    4. Calmodulin is involved in the induction of DNA polymerases alpha and delta activities in normal rat kidney cells activated to proliferate. López-Girona A, et al. Biochem Biophys Res Commun, 1995 Dec 14. PMID 7503737
    5. Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta. Ducoux M, et al. J Biol Chem, 2001 Dec 28. PMID 11595739

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA strand elongation involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in error-prone translesion synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in error-prone translesion synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of delta DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of delta DNA polymerase complex IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of delta DNA polymerase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of delta DNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of delta DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of zeta DNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of zeta DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase delta subunit 2
    Names
    DAN polymerase delta 2, accessory subunit
    DNA polymerase delta subunit p50
    DNA-directed DNA polymerase delta 2
    polymerase (DNA directed), delta 2, accessory subunit
    polymerase (DNA directed), delta 2, regulatory subunit
    polymerase (DNA) delta 2, accessory subunit
    NP_001013068.1
    XP_063129020.1
    XP_063129021.1
    XP_063129022.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013050.1 → NP_001013068.1  DNA polymerase delta subunit 2

      See identical proteins and their annotated locations for NP_001013068.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079267
      UniProtKB/Swiss-Prot
      Q6AXY4
      UniProtKB/TrEMBL
      A0A8L2QAQ7, A6IKQ3
      Related
      ENSRNOP00000072093.3, ENSRNOT00000084633.3
      Conserved Domains (2) summary
      cd07387
      Location:215 → 452
      MPP_PolD2_C; PolD2 (DNA polymerase delta, subunit 2), C-terminal domain
      pfam18018
      Location:49 → 175
      DNA_pol_D_N; DNA polymerase delta subunit OB-fold domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      84962933..84969148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272951.1 → XP_063129021.1  DNA polymerase delta subunit 2 isoform X1

    2. XM_063272952.1 → XP_063129022.1  DNA polymerase delta subunit 2 isoform X2

      UniProtKB/Swiss-Prot
      Q6AXY4
      UniProtKB/TrEMBL
      A6IKQ3

    3. XM_063272950.1 → XP_063129020.1  DNA polymerase delta subunit 2 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AXY4.1 GenPept UniProtKB/Swiss-Prot:Q6AXY4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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