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    Prl2c1 prolactin family 2, subfamily C, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502122, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prl2c1provided by RGD
    Official Full Name
    prolactin family 2, subfamily C, member 1provided by RGD
    Primary source
    RGD:1562878
    See related
    EnsemblRapid:ENSRNOG00000039058 AllianceGenome:RGD:1562878
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ghd4; RGD1562878
    Summary
    Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Prl2c1 in Genome Data Viewer
    Location:
    17p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (37089507..37097827, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (36881099..36889419, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (38849932..38858391, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene prolactin family 4, subfamily A, member 1 Neighboring gene lysophosphatidylcholine acyltransferase 4, pseudogene 1 Neighboring gene prolactin family 2, subfamily A, member 1 Neighboring gene prolactin family 7, subfamily c, member 1

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables prolactin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in female pregnancy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mammary gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of lactation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to nutrient levels IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    prolactin family 2, subfamily C, member 1
    Names
    growth hormone d4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044271.1NP_001037736.1  prolactin family 2, subfamily C, member 1 precursor

      See identical proteins and their annotated locations for NP_001037736.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ329281
      UniProtKB/TrEMBL
      A0A8I5ZRV4, F1LR82, Q1KZI0
      Related
      ENSRNOP00000056493.3, ENSRNOT00000059738.6
      Conserved Domains (1) summary
      cd10288
      Location:29227
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      37089507..37097827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600653.1XP_017456142.1  prolactin family 2, subfamily C, member 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRV4