Nrg2 neuregulin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Nrg2provided by RGD
Full Name: neuregulin 2provided by RGD
Primary source: RGD:1303302
See related: EnsemblRapid:ENSRNOG00000019093 AllianceGenome:RGD:1303302
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ntak; NTAK alpha1; NTAK alpha2a; NTAK_alpha2a
Summary: Enables epidermal growth factor receptor activity and signaling receptor binding activity. Involved in ERBB signaling pathway and regulation of synapse organization. Is active in GABA-ergic synapse; extracellular space; and glutamatergic synapse. Orthologous to human NRG2 (neuregulin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 25.7), Lung (RPKM 23.7) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (27890578..28072538, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (27616542..27798505, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (28835391..29015552, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NRG2 and Kv2.1 are co-regulated components of a shared pathway that responds to elevated extracellular glutamate levels.
Title: NMDA Receptors Regulate Neuregulin 2 Binding to ER-PM Junctions and Ectodomain Release by ADAM10 [corrected].
NTAK/NRG2 secreted from astrocytes bound to ErbB3 on neurons, and promoted neuronal survival and neurite extension in vitro.
Title: NTAK/neuregulin-2 secreted by astrocytes promotes survival and neurite outgrowth of neurons via ErbB3.
These results imply that NRG2 may play a critical role in network integration of newborn neurons
Title: Bidirectional Signaling of Neuregulin-2 Mediates Formation of GABAergic Synapses and Maturation of Glutamatergic Synapses in Newborn Granule Cells of Postnatal Hippocampus.
Findings reveal an intimate reciprocal relationship between ErbB4 and GluN2b NMDA receptors via NRG2/ErbB4 signaling.
Title: A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling.
These results provide a potential role for the previously reported, paradoxical perisynaptic accumulation of Nrg-2alpha, the isoform with the least AChR-inducing activity when presented in a soluble form.
Title: Schwann cell-derived neuregulin-2alpha can function as a cell-attached activator of muscle acetylcholine receptor expression.
In neuronal primary cultures from developing rat hippocampus, neuregulin 2 (NRG-2) is restricted to neuronal somas and dendrites.
Title: Neuregulin-2 is developmentally regulated and targeted to dendrites of central neurons.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D18Rat36 (e-PCR)
- UniSTS:119340

D18Wox22 (e-PCR)
- UniSTS:518713

UniSTS:492223 (e-PCR)
- UniSTS:492223

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ErbB-3 class receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables ErbB-4 class receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables epidermal growth factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables epidermal growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ERBB2-ERBB3 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ERBB4 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERBB4 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ERBB4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ERBB4-ERBB4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in animal organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pro-neuregulin-2, membrane-bound isoform

Names: neural- and thymus-derived activator for ErbB kinases; pro-NRG2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001136151.2 → NP_001129623.2 pro-neuregulin-2, membrane-bound isoform

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

A0A8I6GKI5, D4A078

Related

ENSRNOP00000028713.7, ENSRNOT00000028713.9

Conserved Domains (2) summary

smart00409
Location:259 → 344

IG; Immunoglobulin

cd00054
Location:369 → 397

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

27890578..28072538 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063277502.1 → XP_063133572.1 pro-neuregulin-2, membrane-bound isoform isoform X2

UniProtKB/TrEMBL

A0A8I6A510

Related

ENSRNOP00000087759.1, ENSRNOT00000119243.2
XM_063277501.1 → XP_063133571.1 pro-neuregulin-2, membrane-bound isoform isoform X1

UniProtKB/TrEMBL

A0A8I6AHJ7

Related

ENSRNOP00000093404.1, ENSRNOT00000097771.2
XM_063277503.1 → XP_063133573.1 pro-neuregulin-2, membrane-bound isoform isoform X3
XM_063277504.1 → XP_063133574.1 pro-neuregulin-2, membrane-bound isoform isoform X4

UniProtKB/TrEMBL

F1LM11

Related

ENSRNOP00000025901.8, ENSRNOT00000025902.10
XM_063277506.1 → XP_063133576.1 pro-neuregulin-2, membrane-bound isoform isoform X6
XM_063277505.1 → XP_063133575.1 pro-neuregulin-2, membrane-bound isoform isoform X5
XM_063277507.1 → XP_063133577.1 pro-neuregulin-2, membrane-bound isoform isoform X7
XM_063277508.1 → XP_063133578.1 pro-neuregulin-2, membrane-bound isoform isoform X8