Trpm2 transient receptor potential cation channel, subfamily M, member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trpm2provided by RGD
Official Full Name: transient receptor potential cation channel, subfamily M, member 2provided by RGD
Primary source: RGD:1311889
See related: EnsemblRapid:ENSRNOG00000001216 AllianceGenome:RGD:1311889
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Trpm2-predicted
Summary: Predicted to enable calcium ion binding activity; metal ion transmembrane transporter activity; and mono-ADP-D-ribose binding activity. Involved in several processes, including calcium ion import across plasma membrane; estrous cycle; and positive regulation of cellular response to oxidative stress. Located in neuronal cell body. Biomarker of transient cerebral ischemia. Orthologous to human TRPM2 (transient receptor potential cation channel subfamily M member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 234.5), Liver (RPKM 58.5) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (10703190..10752795)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (10703568..10753189)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (11434062..11482880)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transient receptor potential M2 channel in the hypothalamic preoptic area and its impact on thermoregulation during menopause.
Title: Transient receptor potential M2 channel in the hypothalamic preoptic area and its impact on thermoregulation during menopause.
TRPM2 may be involved in high fructose corn syrup-induced anxiety-like behavior in adult male rats.
Title: TRPM2 may be involved in high fructose corn syrup-induced anxiety-like behavior in adult male rats.
Over-activation of TRPM2 ion channel accelerates blood-spinal cord barrier destruction in diabetes combined with spinal cord injury rat.
Title: Over-activation of TRPM2 ion channel accelerates blood-spinal cord barrier destruction in diabetes combined with spinal cord injury rat.
Pharmacological Inhibition of Transient Receptor Potential Melastatin 2 (TRPM2) Channels Attenuates Diabetes-induced Cognitive Deficits in Rats: A Mechanistic Study.
Title: Pharmacological Inhibition of Transient Receptor Potential Melastatin 2 (TRPM2) Channels Attenuates Diabetes-induced Cognitive Deficits in Rats: A Mechanistic Study.
The effects of TRPM2, TRPM6, TRPM7 and TRPM8 gene expression in hepatic ischemia reperfusion injury.
Title: The effects of TRPM2, TRPM6, TRPM7 and TRPM8 gene expression in hepatic ischemia reperfusion injury.
TRPM2 participates in the transformation of acute pain to chronic pain during injury-induced neuropathic pain
Title: TRPM2 participates the transformation of acute pain to chronic pain during injury-induced neuropathic pain.
Results suggest that the mechanisms of fibromyalgia may be mediated via the TRPM2 and TRPV1 channels by inducing mitochondrial ROS, apoptosis, and pain in the sciatic and dorsal root ganglion. However, the pain, oxidant, and apoptotic effects of fibromyalgia were reversed through the blockage of TRPM2 and TRPV1 in the neurons by Se treatment.
Title: Involvement of TRPM2 and TRPV1 channels on hyperalgesia, apoptosis and oxidative stress in rat fibromyalgia model: Protective role of selenium.
TRPM2 was most highly expressed in microglia with little expression in neurons and astrocytes
Title: mRNA expression of transient receptor potential melastatin (TRPM) channels 2 and 7 in perinatal brain development.
these findings supported the role of TRPM2 channel in reactive oxygen species-induced NLRP3 activation in microglial cells through the exposure to Amyloid-beta
Title: TRPM2 dependence of ROS-induced NLRP3 activation in Alzheimer's disease.
the current results are the first to demonstrate the molecular level effects of Dexmedetomidine (DEX) on TRPM2 and TRPV1 activation. Therefore, DEX can have remarkable neuroprotective impairment effects in the hippocampus and DRG of cerebral ischemia-induced rats.
Title: The neuroprotective action of dexmedetomidine on apoptosis, calcium entry and oxidative stress in cerebral ischemia-induced rats: Contribution of TRPM2 and TRPV1 channels.

Submit: New GeneRIF Correction See all GeneRIFs (25)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables ADP-ribose diphosphatase activity	ISO Inferred from Sequence Orthology more info
NOT enables ADP-ribose diphosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
NOT enables hydrolase activity	ISO Inferred from Sequence Orthology more info
NOT enables hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables intracellularly gated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables intracellularly gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables ligand-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables manganese ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables manganese ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables mono-ADP-D-ribose binding	IEA Inferred from Electronic Annotation more info
enables mono-ADP-D-ribose binding	ISO Inferred from Sequence Orthology more info
enables mono-ADP-D-ribose binding	ISS Inferred from Sequence or Structural Similarity more info
enables monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic cation channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables sodium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in calcium ion import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion transmembrane import into cytosol	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane import into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in cellular response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hydrogen peroxide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to temperature stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to temperature stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to temperature stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in dendritic cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in dendritic cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in dendritic cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in dendritic cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in dendritic cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in dendritic cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in estrous cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in manganese ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within manganese ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of filopodium assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
involved_in release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to heat	IEA Inferred from Electronic Annotation more info
involved_in response to heat	ISO Inferred from Sequence Orthology more info
involved_in response to hydroperoxide	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to hydroperoxide	ISO Inferred from Sequence Orthology more info
involved_in response to purine-containing compound	IEA Inferred from Electronic Annotation more info
involved_in response to purine-containing compound	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in temperature homeostasis	IEA Inferred from Electronic Annotation more info
involved_in temperature homeostasis	ISO Inferred from Sequence Orthology more info
involved_in temperature homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in zinc ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in zinc ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in zinc ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: transient receptor potential cation channel subfamily M member 2

Names: transient receptor potential melastatin family 2

NP_001011559.2

EC 3.6.1.13

XP_006256311.1

EC 3.6.1.13

XP_038954482.1

EC 3.6.1.13

XP_038954483.1

EC 3.6.1.13

XP_038954484.1

EC 3.6.1.13

XP_038954485.1

EC 3.6.1.13

XP_038954487.1

EC 3.6.1.13

XP_038954488.1

EC 3.6.1.13

XP_038954490.1

EC 3.6.1.13

XP_038954491.1

EC 3.6.1.13

XP_038954492.1

EC 3.6.1.13

XP_038954493.1

EC 3.6.1.13

XP_063135120.1

EC 3.6.1.13

XP_063135121.1

EC 3.6.1.13

XP_063135122.1

EC 3.6.1.13

XP_063135123.1

EC 3.6.1.13

XP_063135124.1

EC 3.6.1.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011559.2 → NP_001011559.2 transient receptor potential cation channel subfamily M member 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A0A8L2UH90, A6JK56

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

10703190..10752795

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098555.2 → XP_038954483.1 transient receptor potential cation channel subfamily M member 2 isoform X1

Conserved Domains (4) summary

TIGR00870
Location:717 → 1072

trp; transient-receptor-potential calcium channel protein

pfam00520
Location:801 → 977

Ion_trans; Ion transport protein

cl00447
Location:1361 → 1541

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

cl39032
Location:140 → 363

LSDAT_euk; SLOG in TRPM
XM_039098554.2 → XP_038954482.1 transient receptor potential cation channel subfamily M member 2 isoform X1

Conserved Domains (4) summary

TIGR00870
Location:717 → 1072

trp; transient-receptor-potential calcium channel protein

pfam00520
Location:801 → 977

Ion_trans; Ion transport protein

cl00447
Location:1361 → 1541

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

cl39032
Location:140 → 363

LSDAT_euk; SLOG in TRPM
XM_006256249.5 → XP_006256311.1 transient receptor potential cation channel subfamily M member 2 isoform X3

UniProtKB/Swiss-Prot

E9PTA2, Q2PH54, Q5G856

Conserved Domains (1) summary

cl00447
Location:1323 → 1503

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
XM_039098559.2 → XP_038954487.1 transient receptor potential cation channel subfamily M member 2 isoform X4

Conserved Domains (3) summary

TIGR00870
Location:717 → 1072

trp; transient-receptor-potential calcium channel protein

pfam00520
Location:801 → 977

Ion_trans; Ion transport protein

cl39032
Location:140 → 363

LSDAT_euk; SLOG in TRPM
XM_063279052.1 → XP_063135122.1 transient receptor potential cation channel subfamily M member 2 isoform X6
XM_039098562.1 → XP_038954490.1 transient receptor potential cation channel subfamily M member 2 isoform X7

Conserved Domains (1) summary

cl39032
Location:140 → 363

LSDAT_euk; SLOG in TRPM
XM_039098564.2 → XP_038954492.1 transient receptor potential cation channel subfamily M member 2 isoform X9

Conserved Domains (1) summary

cl39032
Location:140 → 363

LSDAT_euk; SLOG in TRPM
XM_039098563.2 → XP_038954491.1 transient receptor potential cation channel subfamily M member 2 isoform X8

Conserved Domains (1) summary

cl39032
Location:140 → 363

LSDAT_euk; SLOG in TRPM
XM_039098556.2 → XP_038954484.1 transient receptor potential cation channel subfamily M member 2 isoform X1

Conserved Domains (4) summary

TIGR00870
Location:717 → 1072

trp; transient-receptor-potential calcium channel protein

pfam00520
Location:801 → 977

Ion_trans; Ion transport protein

cl00447
Location:1361 → 1541

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

cl39032
Location:140 → 363

LSDAT_euk; SLOG in TRPM
XM_063279050.1 → XP_063135120.1 transient receptor potential cation channel subfamily M member 2 isoform X2

UniProtKB/TrEMBL

A0A8L2UH90, A6JK56

Related

ENSRNOP00000001631.5, ENSRNOT00000001631.7
XM_063279051.1 → XP_063135121.1 transient receptor potential cation channel subfamily M member 2 isoform X3

UniProtKB/Swiss-Prot

E9PTA2, Q2PH54, Q5G856
XM_039098557.2 → XP_038954485.1 transient receptor potential cation channel subfamily M member 2 isoform X1

Conserved Domains (4) summary

TIGR00870
Location:717 → 1072

trp; transient-receptor-potential calcium channel protein

pfam00520
Location:801 → 977

Ion_trans; Ion transport protein

cl00447
Location:1361 → 1541

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

cl39032
Location:140 → 363

LSDAT_euk; SLOG in TRPM
XM_039098560.2 → XP_038954488.1 transient receptor potential cation channel subfamily M member 2 isoform X5

Conserved Domains (3) summary

TIGR00870
Location:190 → 545

trp; transient-receptor-potential calcium channel protein

pfam00520
Location:274 → 450

Ion_trans; Ion transport protein

cl00447
Location:834 → 1014

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
XM_039098565.2 → XP_038954493.1 transient receptor potential cation channel subfamily M member 2 isoform X10

Conserved Domains (2) summary

pfam00520
Location:43 → 219

Ion_trans; Ion transport protein

cl00447
Location:603 → 783

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
XM_063279053.1 → XP_063135123.1 transient receptor potential cation channel subfamily M member 2 isoform X11
XM_063279054.1 → XP_063135124.1 transient receptor potential cation channel subfamily M member 2 isoform X12