S100a11 S100 calcium binding protein A11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: S100a11provided by RGD
Official Full Name: S100 calcium binding protein A11provided by RGD
Primary source: RGD:1303295
See related: EnsemblRapid:ENSRNOG00000010105 AllianceGenome:RGD:1303295
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including S100 protein binding activity; calcium-dependent protein binding activity; and protein homodimerization activity. Predicted to be involved in positive regulation of smooth muscle cell migration. Predicted to be located in nucleus and ruffle. Predicted to be active in cytoplasm and extracellular space. Orthologous to human S100A11 (S100 calcium binding protein A11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 605.9), Kidney (RPKM 299.2) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (181875132..181880542)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (179191688..179197098)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (193863185..193868646)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibitory Effect of S100A11 on Airway Smooth Muscle Contraction and Airway Hyperresponsiveness.
Title: Inhibitory Effect of S100A11 on Airway Smooth Muscle Contraction and Airway Hyperresponsiveness.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

S100a11 (e-PCR), detects polymorphism
- UniSTS:498776

RH142335 (e-PCR)
- UniSTS:231582

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables S100 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables S100 protein binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein S100-A11

Names: S100 calcium binding protein A11 (calizzarin); calgizzarin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004095.2 → NP_001004095.1 protein S100-A11

See identical proteins and their annotated locations for NP_001004095.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q6B345

UniProtKB/TrEMBL

A6KMM4

Related

ENSRNOP00000013393.4, ENSRNOT00000013393.8

Conserved Domains (1) summary

cd05023
Location:2 → 90

S-100A11; S-100A11 domain found in proteins similar to S100A11. S100A11 is a member of the S-100 domain family within EF-hand Ca2+-binding proteins superfamily. Note that the S-100 hierarchy, to which this S-100A11 group belongs, contains only S-100 EF-hand ...