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    Gid8 GID complex subunit 8 homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296466, updated on 27-Nov-2024

    Summary

    Official Symbol
    Gid8provided by RGD
    Official Full Name
    GID complex subunit 8 homologprovided by RGD
    Primary source
    RGD:735024
    See related
    EnsemblRapid:ENSRNOG00000082598 AllianceGenome:RGD:735024
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bwk1; TWA1
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway; positive regulation of cell population proliferation; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cell junction; cytosol; and nucleoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human GID8 (GID complex subunit 8 homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 297.3), Liver (RPKM 199.3) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Gid8 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188203571..188214324)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (167826006..167836759)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (176217128..176223645)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ATP synthase membrane subunit f, pseudogene 2 Neighboring gene death inducer-obliterator 1 Neighboring gene solute carrier family 17 member 9 Neighboring gene basic helix-loop-helix family, member e23 Neighboring gene U4 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glucose-induced degradation protein 8 homolog
    Names
    BWK-1
    Bwk1 leukemia-related
    two hybrid associated protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198743.2NP_942038.1  glucose-induced degradation protein 8 homolog

      See identical proteins and their annotated locations for NP_942038.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AEK9, Q6YDN8
      Related
      ENSRNOP00000103808.1, ENSRNOT00000124655.1
      Conserved Domains (2) summary
      pfam08513
      Location:2852
      LisH
      pfam10607
      Location:63207
      CLTH; CTLH/CRA C-terminal to LisH motif domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      188203571..188214324
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)