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    Tmub1 transmembrane and ubiquitin-like domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362301, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tmub1provided by RGD
    Official Full Name
    transmembrane and ubiquitin-like domain containing 1provided by RGD
    Primary source
    RGD:735120
    See related
    AllianceGenome:RGD:735120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hops
    Summary
    The protein encoded by this gene belongs to a group of integral ubiquitin-like domain containing proteins that are involved in a range of cellular processes. In mouse, the protein exists in uncleaved transmembrane forms as well as a cleaved form that shuttles between the nucleus and cytoplasm. During liver regeneration in rat, it has been shown that the protein shuttles from the cytoplasm to the nucleus to inhibit hepatocyte proliferation. Homozygous null mutant mice display normal development and physiology but exhibit a strong increase in locomoter activity during the dark phase of the light:dark cycle, indicating a function in behavioral regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
    Expression
    Biased expression in Kidney (RPKM 45.3), Thymus (RPKM 41.2) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tmub1 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (11621931..11624497)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (10729494..10732060)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (7257752..7260318)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene gastrulation brain homeobox 1 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Neighboring gene uncharacterized LOC134486542 Neighboring gene Fas-activated serine/threonine kinase Neighboring gene solute carrier family 4 member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC72996

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ERAD pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in postsynaptic neurotransmitter receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic recycling endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transmembrane and ubiquitin-like domain-containing protein 1
    Names
    hepatocyte odd protein shuttling protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080153.2NP_001073622.1  transmembrane and ubiquitin-like domain-containing protein 1

      See identical proteins and their annotated locations for NP_001073622.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      DY313123, JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q53AQ4
      Conserved Domains (1) summary
      cd17131
      Location:101171
      Ubl_TMUB1; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1)
    2. NM_198781.3NP_942076.2  transmembrane and ubiquitin-like domain-containing protein 1

      See identical proteins and their annotated locations for NP_942076.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate exon in the 5' UTR compared to variant 2. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      DY313123, JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q53AQ4
      Conserved Domains (1) summary
      cd17131
      Location:101171
      Ubl_TMUB1; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      11621931..11624497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235945.5XP_006236007.1  transmembrane and ubiquitin-like domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006236007.1

      UniProtKB/Swiss-Prot
      Q53AQ4
      Conserved Domains (1) summary
      cd17131
      Location:101171
      Ubl_TMUB1; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1)