Pon2 paraoxonase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pon2provided by RGD
Official Full Name: paraoxonase 2provided by RGD
Primary source: RGD:1309954
See related: EnsemblRapid:ENSRNOG00000009112 AllianceGenome:RGD:1309954
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable acyl-L-homoserine-lactone lactonohydrolase activity; arylesterase activity; and protein homodimerization activity. Involved in response to oxidative stress. Predicted to be located in plasma membrane. Biomarker of metabolic dysfunction-associated steatotic liver disease and obesity. Human ortholog(s) of this gene implicated in several diseases, including cerebral infarction; familial hypercholesterolemia; neurodegenerative disease (multiple); type 2 diabetes mellitus; and vascular dementia. Orthologous to human PON2 (paraoxonase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 255.2), Spleen (RPKM 185.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (34356270..34391684, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (33389702..33425186, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (30344705..30380119, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lovastatin conferred neuroprotection against MPP(+)-induced Parkinson disease but this effect was not associated with the induction of PON2 in the rat striatum.
Title: The neuroprotective effect of lovastatin on MPP(+)-induced neurotoxicity is not mediated by PON2.
These observations demonstrate that the human intestine is preferentially endowed with a marked PON2 expression compared with the rat intestine and this expression shows a developmental and intracellular pattern of distribution.
Title: Biological role, protein expression, subcellular localization, and oxidative stress response of paraoxonase 2 in the intestine of humans and rats.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acyl-L-homoserine-lactone lactonohydrolase activity	IEA Inferred from Electronic Annotation more info
enables acyl-L-homoserine-lactone lactonohydrolase activity	ISO Inferred from Sequence Orthology more info
enables arylesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arylesterase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in lactone catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lactone catabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serum paraoxonase/arylesterase 2

Names: A-esterase 2; PON 2; aromatic esterase 2; serum aryldialkylphosphatase 2

NP_001013100.1

EC 3.1.1.2

EC 3.1.1.81

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.