Ttc9 tetratricopeptide repeat domain 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ttc9provided by RGD
Official Full Name: tetratricopeptide repeat domain 9provided by RGD
Primary source: RGD:1565985
See related: EnsemblRapid:ENSRNOG00000007254 AllianceGenome:RGD:1565985
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565985
Summary: Predicted to enable protein folding chaperone. Predicted to be involved in negative regulation of apoptotic process and protein folding. Predicted to act upstream of or within bone development. Predicted to be active in several cellular components, including cytosol; endomembrane system; and mitochondrial envelope. Human ortholog(s) of this gene implicated in opiate dependence. Orthologous to human TTC9 (tetratricopeptide repeat domain 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 125.4), Lung (RPKM 72.8) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (107064527..107099361)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (101333274..101368110)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (105364668..105399500)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial envelope	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tetratricopeptide repeat protein 9A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134731.1 → NP_001128203.1 tetratricopeptide repeat protein 9A

See identical proteins and their annotated locations for NP_001128203.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A6JDN6

Related

ENSRNOP00000069448.2, ENSRNOT00000087090.3

Conserved Domains (3) summary

sd00006
Location:129 → 158

TPR; TPR repeat [structural motif]

pfam00515
Location:164 → 196

TPR_1; Tetratricopeptide repeat

pfam13414
Location:126 → 194

TPR_11; TPR repeat