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    Haao 3-hydroxyanthranilate 3,4-dioxygenase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 56823, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Haaoprovided by RGD
    Official Full Name
    3-hydroxyanthranilate 3,4-dioxygenaseprovided by RGD
    Primary source
    RGD:71071
    See related
    EnsemblRapid:ENSRNOG00000031263 AllianceGenome:RGD:71071
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables 3-hydroxyanthranilate 3,4-dioxygenase activity; iron ion binding activity; and oxygen binding activity. Involved in quinolinate metabolic process. Located in mitochondrial membrane. Used to study Huntington's disease. Orthologous to human HAAO (3-hydroxyanthranilate 3,4-dioxygenase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 501.5) and Kidney (RPKM 370.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Haao in Genome Data Viewer
    Location:
    6q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (16598325..16617590)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (10845235..10864863)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (7045145..7059227, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548368 Neighboring gene wiskott-Aldrich syndrome protein family member 1-like Neighboring gene transfer RNA isoleucine (anticodon UAU) 2 Neighboring gene uncharacterized LOC120093196 Neighboring gene metastasis associated 1 family, member 3 Neighboring gene uncharacterized LOC134479096

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Synthesis of quinolinic acid by 3-hydroxyanthranilic acid oxygenase in rat brain tissue in vitro. Foster AC, et al. J Neurochem, 1986 Jul. PMID 2940338
    2. Rat 3-hydroxyanthranilic acid oxygenase: purification from the liver and immunocytochemical localization in the brain. Okuno E, et al. J Neurochem, 1987 Sep. PMID 3112306
    3. Increase in the level of mRNA for 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice. Nakagawa Y, et al. Biosci Biotechnol Biochem, 1995 Nov. PMID 8541664
    4. Effects of oxygen on 3-hydroxyanthranilate oxidase of the kynurenine pathway. Dang Y, et al. Free Radic Biol Med, 1998 Dec. PMID 9870556
    5. Immunohistochemical visualization of newly formed quinolinate in the normal and excitotoxically lesioned rat striatum. Lehrmann E, et al. Exp Brain Res, 2001 Dec. PMID 11715084

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-hydroxyanthranilate 3,4-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-hydroxyanthranilate 3,4-dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-hydroxyanthranilate 3,4-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3-hydroxyanthranilate 3,4-dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ferrous iron binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferrous iron binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables iron ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' NAD biosynthetic process from tryptophan IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' NAD biosynthetic process from tryptophan IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NAD biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in anthranilate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron cellular homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyridine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in quinolinate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in quinolinate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in quinolinate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in quinolinate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to cadmium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to cadmium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to zinc ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to zinc ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tryptophan catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3-hydroxyanthranilate 3,4-dioxygenase
    Names
    3-HAO
    3-hydroxyanthranilate oxygenase
    3-hydroxyanthranilic acid dioxygenase
    HAD
    NP_064461.1
    XP_038968722.1
    XP_063118443.1
    XP_063118444.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020076.2 → NP_064461.1  3-hydroxyanthranilate 3,4-dioxygenase

      See identical proteins and their annotated locations for NP_064461.1

      Status: PROVISIONAL

      Source sequence(s)
      D44494
      UniProtKB/Swiss-Prot
      P46953, P70474, Q5RKK0, Q64556
      UniProtKB/TrEMBL
      A0A0G2JSV5
      Related
      ENSRNOP00000103656.1, ENSRNOT00000131735.1
      Conserved Domains (1) summary
      cl21464
      Location:2 → 149
      cupin_like; Conserved domain found in cupin and related proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      16598325..16617590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112794.2 → XP_038968722.1  3-hydroxyanthranilate 3,4-dioxygenase isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZR59, A0A8I6GEE8
      Related
      ENSRNOP00000085878.1, ENSRNOT00000096657.2
      Conserved Domains (2) summary
      cd06123
      Location:10 → 159
      cupin_HAO; 3-Hydroxyanthranilate-3,4-dioxygenase, cupin domain
      cl40423
      Location:209 → 259
      cupin_RmlC-like; RmlC-like cupin superfamily

    2. XM_063262374.1 → XP_063118444.1  3-hydroxyanthranilate 3,4-dioxygenase isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZR59

    3. XM_063262373.1 → XP_063118443.1  3-hydroxyanthranilate 3,4-dioxygenase isoform X2

      UniProtKB/TrEMBL
      A0A0G2JSV5
      Related
      ENSRNOP00000043835.3, ENSRNOT00000045996.4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46953.2 GenPept UniProtKB/Swiss-Prot:P46953

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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