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    Dbx2 developing brain homeobox 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 541457, updated on 9-Dec-2024

    Summary

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    Symbol
    Dbx2provided by RGD
    Full Name
    developing brain homeobox 2provided by RGD
    Primary source
    RGD:1359605
    See related
    EnsemblRapid:ENSRNOG00000006885 AllianceGenome:RGD:1359605
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human DBX2 (developing brain homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 24.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dbx2 in Genome Data Viewer
    Location:
    7q35
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (128651603..128681886, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (126772389..126802625, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (136966879..136997104, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene neural EGFL like 2 Neighboring gene U4 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102547300 Neighboring gene anoctamin 6 Neighboring gene uncharacterized LOC134479558 Neighboring gene histone deacetylase 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression study of cadherin7 and cadherin20 in the embryonic and adult rat central nervous system. Takahashi M, et al. BMC Dev Biol, 2008 Sep 19. PMID 18801203, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein DBX2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432017.1 → NP_001418946.1  homeobox protein DBX2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6KC08, F1LRM4

    2. NM_001432018.1 → NP_001418947.1  homeobox protein DBX2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6KC08

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      128651603..128681886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242286.4 → XP_006242348.1  homeobox protein DBX2 isoform X2

      Conserved Domains (1) summary
      pfam00046
      Location:197 → 250
      Homeobox; Homeobox domain

    2. XM_001053826.6 → XP_001053826.1  homeobox protein DBX2 isoform X1

      Related
      ENSRNOP00000009143.4, ENSRNOT00000009143.7
      Conserved Domains (1) summary
      pfam00046
      Location:229 → 282
      Homeobox; Homeobox domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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