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    CSRP1 cysteine and glycine rich protein 1 [ Homo sapiens (human) ]

    Gene ID: 1465, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CSRP1provided by HGNC
    Official Full Name
    cysteine and glycine rich protein 1provided by HGNC
    Primary source
    HGNC:HGNC:2469
    See related
    Ensembl:ENSG00000159176 MIM:123876; AllianceGenome:HGNC:2469
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRP; CRP1; CSRP; CYRP; D1S181E; HEL-141; HEL-S-286
    Summary
    This gene encodes a member of the cysteine-rich protein (CSRP) family. This gene family includes a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this gene product occurs in proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]
    Expression
    Broad expression in prostate (RPKM 425.1), endometrium (RPKM 406.6) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CSRP1 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (201483530..201507123, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (200741308..200764907, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (201452658..201476251, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene peptidyl-prolyl cis-trans isomerase NIMA-interacting 4-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2315 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201430707-201431289 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2318 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:201437987-201438701 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2320 Neighboring gene pleckstrin homology like domain family A member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1692 Neighboring gene uncharacterized LOC124904484 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2321 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:201487479-201487990 Neighboring gene CSRP1 antisense RNA 1 Neighboring gene ribosomal protein S10 pseudogene 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201534809-201535310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201535311-201535810 Neighboring gene CRISPRi-validated cis-regulatory element chr1.10615 Neighboring gene neuron navigator 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201560646-201561209 Neighboring gene uncharacterized LOC124904482 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:201591323-201591707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201597565-201598066

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cysteine-rich protein 1 is regulated by transforming growth factor-β1 and expressed in lung fibrosis. Järvinen PM, et al. J Cell Physiol, 2012 Jun. PMID 21882188
    2. Predictive value of plasma asymmetric dimethylarginine, homocysteine, and high-sensitive CRP levels in occult coronary artery disease: A multidetector-row computed tomography study. Gürel E, et al. Herz, 2015 May. PMID 24357092
    3. CSRP1 Promotes Colon Adenocarcinoma Growth and Serves as an Independent Risk Biomarker for Worse Prognosis. Yu S, et al. Genet Res (Camb), 2023. PMID 37113556, Free PMC Article
    4. Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif. Liebhaber SA, et al. Nucleic Acids Res, 1990 Jul 11. PMID 2115670, Free PMC Article
    5. The LIM/double zinc-finger motif functions as a protein dimerization domain. Feuerstein R, et al. Proc Natl Acad Sci U S A, 1994 Oct 25. PMID 7938009, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CSRP1 Promotes Colon Adenocarcinoma Growth and Serves as an Independent Risk Biomarker for Worse Prognosis.
      Title: CSRP1 Promotes Colon Adenocarcinoma Growth and Serves as an Independent Risk Biomarker for Worse Prognosis.
    2. Plasma ADMA is a useful parameter for predicting subclinical atherosclerosis, whereas homocysteine and hsCRP are not
      Title: Predictive value of plasma asymmetric dimethylarginine, homocysteine, and high-sensitive CRP levels in occult coronary artery disease: A multidetector-row computed tomography study.
    3. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
      Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
    4. Results show that CRP1 is a novel TGF-beta1 regulated protein that is expressed in fibrotic lesions and may be relevant in idiopathic pulmonary fibrosis.
      Title: Cysteine-rich protein 1 is regulated by transforming growth factor-β1 and expressed in lung fibrosis.
    5. CRP1 expression is regulated by UVB in human keratinocytes, suggesting a role for CRP1 in the phototoxic responses of human skin.
      Title: Ultraviolet B radiation regulates cysteine-rich protein 1 in human keratinocytes.
    6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    7. Hypomethylation of wingless-related MMTV integration site 5A (WNT5A), S100 calcium-binding protein P (S100P) and cysteine-rich protein 1(CRIP1) was confirmed in the cancer cells by bisulfite sequencing.
      Title: Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer.
    8. Aberrant methylation of CSRP1 is associated with hepatocellular carcinoma
      Title: Methylation status of genes upregulated by demethylating agent 5-aza-2'-deoxycytidine in hepatocellular carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686M148

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables actinin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of muscle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in muscle tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in platelet aggregation HMP PubMed 
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cysteine and glycine-rich protein 1
    Names
    LIM-domain protein
    cysteine-rich protein 1
    epididymis luminal protein 141
    epididymis secretory protein Li 286
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193570.2 → NP_001180499.1  cysteine and glycine-rich protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001180499.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC096677, AK302237, BC032493
      UniProtKB/TrEMBL
      B3KVC9, B4DY28
      Conserved Domains (2) summary
      cd09479
      Location:8 → 63
      LIM1_CRP1; The first LIM domain of Cysteine Rich Protein 1 (CRP1)
      cl02475
      Location:119 → 166
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. NM_001193571.2 → NP_001180500.1  cysteine and glycine-rich protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001180500.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AC096677, AK290133, BC032493
      Consensus CDS
      CCDS1413.1
      UniProtKB/Swiss-Prot
      A8K268, P21291, Q5U0J2
      UniProtKB/TrEMBL
      A0A384P5K2, B3KVC9
      Related
      ENSP00000436792.1, ENST00000533432.5
      Conserved Domains (2) summary
      cd09403
      Location:119 → 172
      LIM2_CRP; The second LIM domain of Cysteine Rich Protein (CRP)
      cd09479
      Location:8 → 63
      LIM1_CRP1; The first LIM domain of Cysteine Rich Protein 1 (CRP1)

    3. NM_001193572.2 → NP_001180501.1  cysteine and glycine-rich protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001180501.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AC096677, AK293053, BC032493
      Consensus CDS
      CCDS1413.1
      UniProtKB/Swiss-Prot
      A8K268, P21291, Q5U0J2
      UniProtKB/TrEMBL
      A0A384P5K2, B3KVC9
      Related
      ENSP00000434147.1, ENST00000532460.5
      Conserved Domains (2) summary
      cd09403
      Location:119 → 172
      LIM2_CRP; The second LIM domain of Cysteine Rich Protein (CRP)
      cd09479
      Location:8 → 63
      LIM1_CRP1; The first LIM domain of Cysteine Rich Protein 1 (CRP1)

    4. NM_004078.3 → NP_004069.1  cysteine and glycine-rich protein 1 isoform 1

      See identical proteins and their annotated locations for NP_004069.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1). Variants 1, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AW163500, BC032493, CA411857, CF453919
      Consensus CDS
      CCDS1413.1
      UniProtKB/Swiss-Prot
      A8K268, P21291, Q5U0J2
      UniProtKB/TrEMBL
      A0A384P5K2, B3KVC9
      Related
      ENSP00000345079.2, ENST00000340006.7
      Conserved Domains (2) summary
      cd09403
      Location:119 → 172
      LIM2_CRP; The second LIM domain of Cysteine Rich Protein (CRP)
      cd09479
      Location:8 → 63
      LIM1_CRP1; The first LIM domain of Cysteine Rich Protein 1 (CRP1)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      201483530..201507123 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      200741308..200764907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001144773.1: Suppressed sequence

      Description
      NM_001144773.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21291.3 GenPept UniProtKB/Swiss-Prot:P21291

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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