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    DLGAP1 DLG associated protein 1 [ Homo sapiens (human) ]

    Gene ID: 9229, updated on 27-Nov-2024

    Summary

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    Official Symbol
    DLGAP1provided by HGNC
    Official Full Name
    DLG associated protein 1provided by HGNC
    Primary source
    HGNC:HGNC:2905
    See related
    Ensembl:ENSG00000170579 MIM:605445; AllianceGenome:HGNC:2905
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DAP1; GKAP; DAP-1; SAPAP1; DLGAP1A; DLGAP1B; DAP-1-BETA; DAP-1-ALPHA
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be a structural constituent of postsynaptic density. Predicted to be involved in several processes, including aggresome assembly; protein localization to synapse; and regulation of proteasomal protein catabolic process. Predicted to be located in plasma membrane. Predicted to be active in glutamatergic synapse and postsynaptic density, intracellular component. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in brain (RPKM 19.8), testis (RPKM 1.7) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DLGAP1 in Genome Data Viewer
    Location:
    18p11.31
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (3496032..4455307, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (3655540..4615578, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (3496030..4455307, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904237 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9254 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:3448381-3449002 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:3449003-3449622 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:3451487-3452108 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:3452731-3453350 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:3452109-3452730 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9257 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9256 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9255 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:3455215-3455834 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:3457616-3458176 Neighboring gene uncharacterized LOC105371965 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:3466751-3467438 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:3469136-3469926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13048 Neighboring gene TGFB induced factor homeobox 1 Neighboring gene Sharpr-MPRA regulatory region 485 Neighboring gene gastric adenocarcinoma associated, positive CD44 regulator, long intergenic non-coding RNA Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr18:3554877-3555427 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:3576467-3576966 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:3575965-3576466 Neighboring gene zinc finger protein 592 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13050 Neighboring gene Sharpr-MPRA regulatory region 8249 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:3595284-3596254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:3596255-3597226 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:3601961-3602755 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:3603326-3604525 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:3610951-3611462 Neighboring gene DLGAP1 antisense RNA 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:3623835-3625034 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:3625199-3625770 Neighboring gene RNA, 7SL, cytoplasmic 39, pseudogene Neighboring gene DLGAP1 antisense RNA 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:3652584-3653783 Neighboring gene Sharpr-MPRA regulatory region 6172 Neighboring gene DLGAP1 antisense RNA 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9258 Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG hESC enhancer GRCh37_chr18:3821582-3822083 Neighboring gene uncharacterized LOC124904238 Neighboring gene DLGAP1 antisense RNA 3 Neighboring gene RNA, U6 small nuclear 831, pseudogene Neighboring gene microRNA 6718 Neighboring gene DLGAP1 antisense RNA 4 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr18:4017491-4018172 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 66 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:4117736-4118323 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:4119078-4119849 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:4118324-4118910 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:4124501-4125480 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:4125481-4126460 Neighboring gene uncharacterized LOC124904239 Neighboring gene Sharpr-MPRA regulatory region 11006 Neighboring gene NANOG hESC enhancer GRCh37_chr18:4195745-4196246 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47861 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47879 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:4233399-4234316 Neighboring gene DLGAP1 antisense RNA 5 Neighboring gene Sharpr-MPRA regulatory region 437 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:4407683-4407856 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9259 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:4477591-4478233 Neighboring gene uncharacterized LOC105371968 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:4494750-4495406 Neighboring gene elongin C pseudogene 27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Whole Genome Linkage and Association Analyses Identify DLG Associated Protein-1 as a Novel Positional and Biological Candidate Gene for Muscle Strength: The Long Life Family Study. Santanasto AJ, et al. J Gerontol A Biol Sci Med Sci, 2024 Aug 1. PMID 38808484,
    2. Genetic analysis of the DLGAP1 gene as a candidate gene for schizophrenia. Li JM, et al. Psychiatry Res, 2013 Jan 30. PMID 22940546
    3. Genome-Wide Association Study of HIV-Related Lipoatrophy in Thai Patients: Association of a DLGAP1 Polymorphism with Fat Loss. Uttayamakul S, et al. AIDS Res Hum Retroviruses, 2015 Aug. PMID 25950743, Free PMC Article
    4. DLGAP1 and NMDA receptor-associated postsynaptic density protein genes influence executive function in attention deficit hyperactivity disorder. Fan Z, et al. Brain Behav, 2018 Feb. PMID 29484270, Free PMC Article
    5. A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population. Takahashi Y, et al. Sci Rep, 2021 Sep 30. PMID 34593835, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Whole Genome Linkage and Association Analyses Identify DLG Associated Protein-1 as a Novel Positional and Biological Candidate Gene for Muscle Strength: The Long Life Family Study.
      Title: Whole Genome Linkage and Association Analyses Identify DLG Associated Protein-1 as a Novel Positional and Biological Candidate Gene for Muscle Strength: The Long Life Family Study.
    2. Deciphering the Role of miR-30a-5p and DLGAP1 Gene in Non-small Cell Lung Cancer.
      Title: Deciphering the Role of miR-30a-5p and DLGAP1 Gene in Non-small Cell Lung Cancer.
    3. DLGAP1-AS2 promotes estrogen receptor signalling and confers tamoxifen resistance in breast cancer.
      Title: DLGAP1-AS2 promotes estrogen receptor signalling and confers tamoxifen resistance in breast cancer.
    4. N(6)-methyladenosine (m(6)A)-mediated lncRNA DLGAP1-AS1enhances breast canceradriamycin resistance through miR-299-3p/WTAP feedback loop.
      Title: N(6)-methyladenosine (m(6)A)-mediated lncRNA DLGAP1-AS1enhances breast canceradriamycin resistance through miR-299-3p/WTAP feedback loop.
    5. A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population.
      Title: A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population.
    6. LncRNA DLGAP1-AS2 modulates glioma development by up-regulating YAP1 expression.
      Title: LncRNA DLGAP1-AS2 modulates glioma development by up-regulating YAP1 expression.
    7. The top SNP rs2049161 involved gene DLGAP1 and the top gene CADPS2 in the gene-based analysis resulted in much literature evidence of associations with psychiatric disorders. Gene expression and network analysis showed their contribution to cognition function.
      Title: Genetic analysis for cognitive flexibility in the trail-making test in attention deficit hyperactivity disorder patients from single nucleotide polymorphism, gene to pathway level.
    8. We demonstrated that miR-148a was upregulated, DLGAP1 was downregulated in glioblastoma, and DLGAP1 was a direct target of miR-148a.
      Title: The role of microRNA-148a and downstream DLGAP1 on the molecular regulation and tumor progression on human glioblastoma.
    9. Study presents evidence that the expression of GKAP modulates the activity of the glutamate-to-NMDAR signaling pathway and promotes invasiveness in mouse neuroendocrine (PanNET) and in both mouse and human ductal (PDAC) cancer cell lines.
      Title: GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth.
    10. Association of two significant SNPs of DLGAP1 with cognitive flexibility in Attention Deficit Hyperactivity Disorder was observed.
      Title: DLGAP1 and NMDA receptor-associated postsynaptic density protein genes influence executive function in attention deficit hyperactivity disorder.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.
    EBI GWAS Catalog
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog
    Genome-wide association analysis of eating disorder-related symptoms, behaviors, and personality traits.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog
    The genetic architecture of economic and political preferences.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of discs, large (Drosophila) homolog-associated protein 1 (DLGAP1; LOC284214) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ38442, MGC88156

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic specialization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    disks large-associated protein 1
    Names
    PSD-95/SAP90 binding protein 1
    SAP90/PSD-95-associated protein 1
    discs large homolog associated protein 1
    guanylate kinase-associated protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003809.3 → NP_001003809.1  disks large-associated protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001003809.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AB000276, AK095761, AK294747, AK316099, AP002472, BC136453, CR743383
      Consensus CDS
      CCDS42406.1
      UniProtKB/TrEMBL
      B7Z2J5
      Related
      ENSP00000383011.2, ENST00000400147.6
      Conserved Domains (1) summary
      pfam03359
      Location:343 → 675
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    2. NM_001242761.2 → NP_001229690.1  disks large-associated protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001229690.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (3) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK316099, AP005241, AP005403, U67988
      Consensus CDS
      CCDS56053.1
      UniProtKB/TrEMBL
      B7Z8W9
      Related
      ENSP00000463864.1, ENST00000581527.5
      Conserved Domains (1) summary
      pfam03359
      Location:645 → 911
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    3. NM_001242762.2 → NP_001229691.1  disks large-associated protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001229691.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks a portion of the 5' UTR and 5' coding region, initiates translation at an alternate start codon, and has multiple coding region differences, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AB000277, AK095761, AK294717, AP002472, CR743383
      Consensus CDS
      CCDS56052.1
      UniProtKB/TrEMBL
      B7Z2J5
      Related
      ENSP00000437817.1, ENST00000534970.5
      Conserved Domains (1) summary
      pfam03359
      Location:329 → 661
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    4. NM_001242763.2 → NP_001229692.1  disks large-associated protein 1 isoform 5

      See identical proteins and their annotated locations for NP_001229692.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks a portion of the 5' UTR and 5' coding region, initiates translation at an alternate start codon, and has multiple coding region differences, compared to variant 1. The encoded isoform (5) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AB000276, AK095761, AK294717, AK294777, AP002472, AP002478, CR743383
      Consensus CDS
      CCDS74191.1
      UniProtKB/TrEMBL
      A0A0A0MTP4, B7Z2J5
      Related
      ENSP00000445973.2, ENST00000515196.6
      Conserved Domains (1) summary
      pfam03359
      Location:367 → 699
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    5. NM_001242764.2 → NP_001229693.1  disks large-associated protein 1 isoform 6

      See identical proteins and their annotated locations for NP_001229693.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (5) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AB000276, AK095761, AK299880, AP002472, AP005204, BC136453, CR743383
      Consensus CDS
      CCDS56051.1
      UniProtKB/TrEMBL
      A8MYR7
      Related
      ENSP00000383019.1, ENST00000400155.5
      Conserved Domains (1) summary
      pfam03359
      Location:351 → 683
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    6. NM_001242765.2 → NP_001229694.1  disks large-associated protein 1 isoform 7

      See identical proteins and their annotated locations for NP_001229694.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks a portion of the 5' UTR and 5' coding region, initiates translation at an alternate start codon, and uses an alternate splice site in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (7) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK294747, U67988
      Consensus CDS
      CCDS56049.1
      UniProtKB/TrEMBL
      B7Z2J5
      Related
      ENSP00000383010.2, ENST00000400145.6
      Conserved Domains (1) summary
      pfam03359
      Location:343 → 609
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    7. NM_001242766.2 → NP_001229695.1  disks large-associated protein 1 isoform 8

      See identical proteins and their annotated locations for NP_001229695.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks a portion of the 5' UTR and 5' coding region, initiates translation at an alternate start codon, and has multiple coding region differences, compared to variant 1. The encoded isoform (8) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AB000276, AK095761, AK294747, AP002472, BC136453, CR743383
      Consensus CDS
      CCDS56050.1
      UniProtKB/TrEMBL
      B7Z2J5
      Related
      ENSP00000446312.1, ENST00000539435.5
      Conserved Domains (1) summary
      pfam03359
      Location:353 → 685
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    8. NM_001308390.2 → NP_001295319.1  disks large-associated protein 1 isoform 9

      See identical proteins and their annotated locations for NP_001295319.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon, and contains an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (9) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AP002472, AP002478, AP005204
      Consensus CDS
      CCDS77146.1
      UniProtKB/TrEMBL
      A8MXQ8, B7Z2J5
      Related
      ENSP00000383014.3, ENST00000400150.7
      Conserved Domains (1) summary
      pfam03359
      Location:361 → 693
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    9. NM_001398525.1 → NP_001385454.1  disks large-associated protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AP002472, AP002478, AP005130, AP005204, AP005241, AP005403
      Conserved Domains (1) summary
      pfam03359
      Location:655 → 987
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    10. NM_001398526.1 → NP_001385455.1  disks large-associated protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AP002472, AP002478, AP005130, AP005204, AP005241, AP005403
      Conserved Domains (1) summary
      pfam03359
      Location:655 → 987
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    11. NM_001398527.1 → NP_001385456.1  disks large-associated protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AP002472, AP002478, AP005130, AP005204, AP005241, AP005403
      Consensus CDS
      CCDS11836.1
      UniProtKB/Swiss-Prot
      A8MWN8, B2RMU8, B7WPA1, B7Z2H2, B7Z2I2, B7Z9Y4, O14489, O14490, P78335
      Conserved Domains (1) summary
      pfam03359
      Location:645 → 977
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    12. NM_001398528.1 → NP_001385457.1  disks large-associated protein 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AP002472, AP002478, AP005130, AP005204, AP005241, AP005403

    13. NM_001398530.1 → NP_001385459.1  disks large-associated protein 1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AP002472, AP002478, AP005204

    14. NM_001398531.1 → NP_001385460.1  disks large-associated protein 1 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AP002472, AP002478, AP005204
      Conserved Domains (1) summary
      pfam03359
      Location:399 → 731
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    15. NM_001398532.1 → NP_001385461.1  disks large-associated protein 1 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AP002472, AP002478, AP005204
      Related
      ENSP00000383013.3, ENST00000400149.7
      Conserved Domains (1) summary
      pfam03359
      Location:363 → 695
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    16. NM_001398533.1 → NP_001385462.1  disks large-associated protein 1 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AP002472, AP002478, AP005204
      Conserved Domains (1) summary
      pfam03359
      Location:357 → 689
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    17. NM_001398534.1 → NP_001385463.1  disks large-associated protein 1 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AP002472, AP002478, AP005204
      Conserved Domains (1) summary
      pfam03359
      Location:353 → 685
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    18. NM_001398535.1 → NP_001385464.1  disks large-associated protein 1 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AP002472, AP002478, AP005204

    19. NM_001398536.1 → NP_001385465.1  disks large-associated protein 1 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AP002472, AP002478, AP005204

    20. NM_001398537.1 → NP_001385466.1  disks large-associated protein 1 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AP002472, AP002478, AP005204
      UniProtKB/TrEMBL
      A0A9L9PY43
      Related
      ENSP00000516677.1, ENST00000706956.1

    21. NM_001398539.1 → NP_001385468.1  disks large-associated protein 1 isoform 20

      Status: VALIDATED

      Source sequence(s)
      AP002472, AP002478, AP005204

    22. NM_001398540.1 → NP_001385469.1  disks large-associated protein 1 isoform 21

      Status: VALIDATED

      Source sequence(s)
      AP002472, AP002478, AP005204

    23. NM_001398541.1 → NP_001385470.1  disks large-associated protein 1 isoform 22

      Status: VALIDATED

      Source sequence(s)
      AP002472, AP002478, AP005204

    24. NM_001398542.1 → NP_001385471.1  disks large-associated protein 1 isoform 23

      Status: VALIDATED

      Source sequence(s)
      AP002472, AP002478, AP005204

    25. NM_001398543.1 → NP_001385472.1  disks large-associated protein 1 isoform 24

      Status: VALIDATED

      Source sequence(s)
      AP002472, AP002478, AP005204
      Conserved Domains (1) summary
      pfam03359
      Location:353 → 619
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    26. NM_001398544.1 → NP_001385473.1  disks large-associated protein 1 isoform 25

      Status: VALIDATED

      Source sequence(s)
      AP002472, AP002478, AP005204

    27. NM_001398545.1 → NP_001385474.1  disks large-associated protein 1 isoform 26

      Status: VALIDATED

      Source sequence(s)
      AP002472, AP002478, AP005204
      Conserved Domains (1) summary
      pfam03359
      Location:351 → 617
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    28. NM_001398546.1 → NP_001385475.1  disks large-associated protein 1 isoform 27

      Status: VALIDATED

      Source sequence(s)
      AP002472, AP002478, AP005204

    29. NM_004746.4 → NP_004737.2  disks large-associated protein 1 isoform 1

      See identical proteins and their annotated locations for NP_004737.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest variant and encodes the longest isoform (1).
      Source sequence(s)
      AK095761, AK316099, AP002472, AP005241, AP005403, BC136453, CR743383
      Consensus CDS
      CCDS11836.1
      UniProtKB/Swiss-Prot
      A8MWN8, B2RMU8, B7WPA1, B7Z2H2, B7Z2I2, B7Z9Y4, O14489, O14490, P78335
      UniProtKB/TrEMBL
      B7Z8W9
      Related
      ENSP00000316377.3, ENST00000315677.8
      Conserved Domains (1) summary
      pfam03359
      Location:645 → 977
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      3496032..4455307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047437933.1 → XP_047293889.1  disks large-associated protein 1 isoform X2

      UniProtKB/Swiss-Prot
      A8MWN8, B2RMU8, B7WPA1, B7Z2H2, B7Z2I2, B7Z9Y4, O14489, O14490, P78335

    2. XM_024451288.2 → XP_024307056.1  disks large-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      B7Z8W9
      Conserved Domains (1) summary
      pfam03359
      Location:655 → 987
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    3. XM_047437934.1 → XP_047293890.1  disks large-associated protein 1 isoform X3

    4. XM_017026080.2 → XP_016881569.1  disks large-associated protein 1 isoform X4

      UniProtKB/TrEMBL
      A8MYR7

    5. XM_047437936.1 → XP_047293892.1  disks large-associated protein 1 isoform X6

      UniProtKB/TrEMBL
      Q6IS01

    6. XM_011525771.4 → XP_011524073.1  disks large-associated protein 1 isoform X6

      See identical proteins and their annotated locations for XP_011524073.1

      UniProtKB/TrEMBL
      Q6IS01

    7. XM_047437935.1 → XP_047293891.1  disks large-associated protein 1 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      3655540..4615578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319361.1 → XP_054175336.1  disks large-associated protein 1 isoform X2

      UniProtKB/Swiss-Prot
      A8MWN8, B2RMU8, B7WPA1, B7Z2H2, B7Z2I2, B7Z9Y4, O14489, O14490, P78335

    2. XM_054319360.1 → XP_054175335.1  disks large-associated protein 1 isoform X1

    3. XM_054319362.1 → XP_054175337.1  disks large-associated protein 1 isoform X3

    4. XM_054319363.1 → XP_054175338.1  disks large-associated protein 1 isoform X4

    5. XM_054319366.1 → XP_054175341.1  disks large-associated protein 1 isoform X6

      UniProtKB/TrEMBL
      Q6IS01

    6. XM_054319365.1 → XP_054175340.1  disks large-associated protein 1 isoform X6

      UniProtKB/TrEMBL
      Q6IS01

    7. XM_054319364.1 → XP_054175339.1  disks large-associated protein 1 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14490.1 GenPept UniProtKB/Swiss-Prot:O14490

    Gene LinkOut

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