Psn Presenilin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Psnprovided by FlyBase
Official Full Name: Presenilinprovided by FlyBase
Primary source: FLYBASE:FBgn0284421
Locus tag: Dmel_CG18803
See related: AllianceGenome:FB:FBgn0284421
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0480/15; 0493/14; 493/14; CG18803; CG5868; Dmel\CG18803; DmPS; Dps; DPS; dPsn; DPsn; DrosPS; gamma-secretase; l(3)77CDb; l(3)S048015a; l(3)S049314; l(3)S049314a; pres; PS; PS1; psn; PSN
Summary: Enables aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Involved in several processes, including amyloid-beta formation; learning or memory; and membrane protein proteolysis. Located in apical plasma membrane; late endosome; and recycling endosome. Part of gamma-secretase complex. Is expressed in several structures, including anterior-posterior subdivision of organism; female germline cell; imaginal disc; pigment cell; and wing vein. Used to study Alzheimer's disease; Alzheimer's disease 3; dilated cardiomyopathy; and early-onset Parkinson's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease (multiple); breast cancer; dilated cardiomyopathy (multiple); frontotemporal dementia (multiple); and hidradenitis suppurativa. Orthologous to human PSEN1 (presenilin 1) and PSEN2 (presenilin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 77C3-77C3; 3-47 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (20432468..20435156)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (20425568..20428256)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Muscle Psn gene combined with exercise contribute to healthy aging of skeletal muscle and lifespan by adaptively regulating Sirt1/PGC-1alpha and arm pathway.
Title: Muscle Psn gene combined with exercise contribute to healthy aging of skeletal muscle and lifespan by adaptively regulating Sirt1/PGC-1α and arm pathway.
Psn is required for neuronal survival during aging and normal lifespan.
Title: An Evolutionarily Conserved Role of Presenilin in Neuronal Protection in the Aging Drosophila Brain.
findings suggest that a normal function of presenilin (PS)is to repress kinesin-1 and dynein motor activity during axonal transport of amyloid precursor protein (APP) vesicles; perturbations of APP/PS transport could contribute to early neuropathology observed in Alzheimer's Diseaseprecursor protein (APP) vesicles
Title: Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo.
a conserved role for presenilin in mediating copper uptake
Title: Presenilin promotes dietary copper uptake.
The interaction of Sanpodo with Presenilin, a component of the gamma-secretase complex, is required for Notch activation.
Title: Sanpodo controls sensory organ precursor fate by directing Notch trafficking and binding γ-secretase.
Consistent with its role in Psn processing, Hbs genetically interacts with the Drosophila beta-amyloid protein precursor-like (Appl) protein.
Title: Hibris, a Drosophila nephrin homolog, is required for presenilin-mediated Notch and APP-like cleavages.
Loss of presenilin causes significantly decreased Notch signaling and neuron apoptosis and increased cytoplasm calcium.
Title: [Advances on Drosophila presenilin gene].
Psn regulates CBP levels in the adult fly brain in a manner that is independent of Notch signaling
Title: Presenilin controls CBP levels in the adult Drosophila central nervous system.
loss of ept alters nuclear cell cycle control in developing imaginal discs and the DaPKC, presenilin, and rbf1 genes as modifiers of molecular and cellular phenotypes that result from loss of ept
Title: Functional interactions between the erupted/tsg101 growth suppressor gene and the DaPKC and rbf1 genes in Drosophila imaginal disc tumors.
presenilin plays a role in regulating intracellular calcium stores
Title: Intracellular calcium deficits in Drosophila cholinergic neurons expressing wild type or FAD-mutant presenilin.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables aspartic endopeptidase activity, intramembrane cleaving	IDA Inferred from Direct Assay more info	PubMed
enables aspartic endopeptidase activity, intramembrane cleaving	IEA Inferred from Electronic Annotation more info
enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch receptor processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Notch receptor processing, ligand-dependent	IDA Inferred from Direct Assay more info	PubMed
involved_in Notch receptor processing, ligand-dependent	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amyloid-beta formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in amyloid-beta formation	IDA Inferred from Direct Assay more info	PubMed
involved_in amyloid-beta formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in copper ion import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane protein ectodomain proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in protein processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein processing	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in short-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of gamma-secretase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of gamma-secretase complex	IDA Inferred from Direct Assay more info	PubMed
part_of gamma-secretase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: presenilin

Names: CG18803-PA; CG18803-PB; CG18803-PC; CG18803-PD; CG18803-PE; Psn-PA; Psn-PB; Psn-PC; Psn-PD; Psn-PE; dPresenilin; gamma-secretase; gamma-secretase component; lethal (3) S048015a; lethal (3) S049314a; pre-senelin