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    BckdhB Branched chain keto acid dehydrogenase E1 subunit beta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355069, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BckdhBprovided by FlyBase
    Official Full Name
    Branched chain keto acid dehydrogenase E1 subunit betaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039993
    Locus tag
    Dmel_CG17691
    See related
    AllianceGenome:FB:FBgn0039993
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bckdhB; CG17691; Dmel\CG17691
    Summary
    Predicted to enable catalytic activity. Predicted to contribute to 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity and branched-chain alpha-keto acid dehydrogenase activity. Predicted to be involved in branched-chain amino acid catabolic process and response to nutrient. Predicted to be located in mitochondrion. Predicted to be part of branched-chain alpha-ketoacid dehydrogenase complex and oxoglutarate dehydrogenase complex. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human BCKDHB (branched chain keto acid dehydrogenase E1 subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See BckdhB in Genome Data Viewer
    Location:
    41A1-41A1; 2-55 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (1590484..1596457)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44043 Neighboring gene lethal (2) 41Ab Neighboring gene Maf1 Neighboring gene pseudo Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NT_033778.4 Chromosome 2R Reference Release 6 plus ISO1 MT Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reduced branched-chain aminotransferase activity alleviates metabolic vulnerability caused by dim light exposure at night in Drosophila. Kim M, et al. J Neurogenet, 2023 Mar-Dec. PMID 36415929
    2. The alpha-ketoacid dehydrogenase complexes of Drosophila melanogaster. Marygold SJ. MicroPubl Biol, 2024. PMID 38741935, Free PMC Article
    3. Cytogenetic and molecular characterization of heterochromatin gene models in Drosophila melanogaster. Rossi F, et al. Genetics, 2007 Feb. PMID 17110485, Free PMC Article
    4. Drosophila as a diet discovery tool for treating amino acid disorders. Mele S, et al. Trends Endocrinol Metab, 2023 Feb. PMID 36567227
    5. Comparative Genomic Analyses Provide New Insights into the Evolutionary Dynamics of Heterochromatin in Drosophila. Caizzi R, et al. PLoS Genet, 2016 Aug. PMID 27513559, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to branched-chain alpha-keto acid dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in branched-chain amino acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in branched-chain amino acid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to nutrient IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of branched-chain alpha-ketoacid dehydrogenase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of oxoglutarate dehydrogenase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    branched chain keto acid dehydrogenase E1 subunit beta
    Names
    BckdhB-PC
    BckdhB-PE
    BckdhB-PF
    CG17691-PC
    CG17691-PE
    CG17691-PF
    branched-chain a-keto acid dehydrogenase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      1590484..1596457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001110548.2 → NP_001104018.1  branched chain keto acid dehydrogenase E1 subunit beta, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001104018.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8QHW9, Q7PLE6, Q8SZ03
      Conserved Domains (3) summary
      cd07036
      Location:48 → 213
      TPP_PYR_E1-PDHc-beta_like; Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins
      PTZ00182
      Location:10 → 362
      PTZ00182; 3-methyl-2-oxobutanate dehydrogenase; Provisional
      pfam02780
      Location:233 → 353
      Transketolase_C; Transketolase, C-terminal domain

    2. NM_001015354.4 → NP_001015354.3  branched chain keto acid dehydrogenase E1 subunit beta, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015354.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8QHW9, Q7PLE6, Q8SZ03
      Conserved Domains (3) summary
      cd07036
      Location:48 → 213
      TPP_PYR_E1-PDHc-beta_like; Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins
      PTZ00182
      Location:10 → 362
      PTZ00182; 3-methyl-2-oxobutanate dehydrogenase; Provisional
      pfam02780
      Location:233 → 353
      Transketolase_C; Transketolase, C-terminal domain

    3. NM_001110546.2 → NP_001104016.2  branched chain keto acid dehydrogenase E1 subunit beta, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001104016.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8QHW8, L7S0L4
      Conserved Domains (1) summary
      cl11410
      Location:48 → 106
      TPP_enzyme_PYR; Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8QHW8 A8QHW8
    Q7PLE6 Q7PLE6
    Q8SZ03 Q8SZ03

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