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    CG18745 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 59141, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG18745provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0042102
    Locus tag
    Dmel_CG18745
    See related
    AllianceGenome:FB:FBgn0042102
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG18745
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in extracellular vesicle biogenesis and protein transport. Predicted to be located in extracellular vesicle. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to several human genes including ARRDC2 (arrestin domain containing 2); ARRDC3 (arrestin domain containing 3); and ARRDC4 (arrestin domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG18745 in Genome Data Viewer
    Location:
    84E1-84E1; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7783843..7786119, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3609565..3611841, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46226 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A GATA/RUNX cis-regulatory module couples Drosophila blood cell commitment and differentiation into crystal cells. Ferjoux G, et al. Dev Biol, 2007 May 15. PMID 17418114
    2. Photoperiod-Dependent Expression of MicroRNA in Drosophila. Pegoraro M, et al. Int J Mol Sci, 2022 Apr 29. PMID 35563325, Free PMC Article
    3. A Drosophila protein-interaction map centered on cell-cycle regulators. Stanyon CA, et al. Genome Biol, 2004. PMID 15575970, Free PMC Article
    4. Comparative interactome analysis of α-arrestin families in human and Drosophila. Lee KT, et al. Elife, 2024 Jan 25. PMID 38270169, Free PMC Article
    5. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in extracellular vesicle biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG18745-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7783843..7786119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_144391.3 → NP_652648.1  uncharacterized protein Dmel_CG18745 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652648.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7L0
      Related
      FBpp0081273
      Conserved Domains (2) summary
      pfam00339
      Location:5 → 150
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
      pfam02752
      Location:174 → 304
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I7L0 Q9I7L0

    Gene LinkOut

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