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    CG6271 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43252, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6271provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039476
    Locus tag
    Dmel_CG6271
    See related
    AllianceGenome:FB:FBgn0039476
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    DmelL1; Dmel\CG6271
    Summary
    Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6271 in Genome Data Viewer
    Location:
    97D14-97D14; 3-92 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27024968..27026109, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22850690..22851831, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene RYamide receptor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene TweedleT Neighboring gene Neprilysin 5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Altered lipid homeostasis in Drosophila InsP3 receptor mutants leads to obesity and hyperphagia. Subramanian M, et al. Dis Model Mech, 2013 May. PMID 23471909, Free PMC Article
    2. ATF4 Responds to Metabolic Stress in Drosophila. Ok S, et al. Front Biosci (Landmark Ed), 2023 Dec 26. PMID 38179767
    3. Analysis of hunger-driven gene expression in the Drosophila melanogaster larval central nervous system. Ryuda M, et al. Zoolog Sci, 2008 Jul. PMID 18828662
    4. Quantitative evolutionary genomics: differential gene expression and male reproductive success in Drosophila melanogaster. Drnevich JM, et al. Proc Biol Sci, 2004 Nov 7. PMID 15539352, Free PMC Article
    5. Germline-dependent gene expression in distant non-gonadal somatic tissues of Drosophila. Parisi MJ, et al. BMC Genomics, 2010 Jun 1. PMID 20515475, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6271-PA
    triglyceride lipase
    NP_651526.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27024968..27026109 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143269.3 → NP_651526.1  uncharacterized protein Dmel_CG6271 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651526.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VB88
      Related
      FBpp0084519
      Conserved Domains (2) summary
      cd00707
      Location:68 → 333
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
      pfam00151
      Location:57 → 337
      Lipase; Lipase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VB88 Q9VB88

    Gene LinkOut

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