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    Neurl4 Neuralized E3 ubiquitin protein ligase 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39558, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Neurl4provided by FlyBase
    Official Full Name
    Neuralized E3 ubiquitin protein ligase 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0283503
    Locus tag
    Dmel_CG46284
    See related
    AllianceGenome:FB:FBgn0283503
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    blue; Blue; CG46284; CG6451; Dmel\CG46284
    Summary
    Predicted to enable ubiquitin protein ligase activity. Located in centrosome. Is expressed in primordial germ cell. Orthologous to human NEURL4 (neuralized E3 ubiquitin protein ligase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Neurl4 in Genome Data Viewer
    Location:
    70C15-70D1; 3-41 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14043694..14049892, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14036794..14042992, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR42871 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Heat shock protein 110 Neighboring gene antisense RNA:CR46067 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Formin-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neurl4 contributes to germ cell formation and integrity in Drosophila. Jones J, et al. Biol Open, 2015 Jun 26. PMID 26116656, Free PMC Article
    2. Unique and Overlapping Functions of Formins Frl and DAAM During Ommatidial Rotation and Neuronal Development in Drosophila. Dollar G, et al. Genetics, 2016 Mar. PMID 26801180, Free PMC Article
    3. DNA supercoiling factor contributes to dosage compensation in Drosophila. Furuhashi H, et al. Development, 2006 Nov. PMID 17035293
    4. The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway. Imai Y, et al. PLoS Genet, 2015 Sep. PMID 26355680, Free PMC Article
    5. Population-scale long-read sequencing uncovers transposable elements associated with gene expression variation and adaptive signatures in Drosophila. Rech GE, et al. Nat Commun, 2022 Apr 12. PMID 35413957, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuralized E3 ubiquitin protein ligase 4
    Names
    CG46284-PA
    Neurl4-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14043694..14049892 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140431.3 → NP_648688.2  neuralized E3 ubiquitin protein ligase 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648688.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1L4AAD6, Q32KB8
      Related
      FBpp0401556
      Conserved Domains (2) summary
      smart00588
      Location:221 → 345
      NEUZ; domain in neuralized proteins
      cd12887
      Location:467 → 629
      SPRY_NHR_like; SPRY domain in neuralized homology repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A1L4AAD6 A0A1L4AAD6

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