Chmp1 Charged multivesicular body protein 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Chmp1provided by FlyBase
Official Full Name: Charged multivesicular body protein 1provided by FlyBase
Primary source: FLYBASE:FBgn0036805
Locus tag: Dmel_CG4108
See related: AllianceGenome:FB:FBgn0036805
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4108; CHMP1; Dmel\CG4108; VPS46
Summary: Predicted to be involved in endosome transport via multivesicular body sorting pathway; late endosome to vacuole transport; and protein transport. Located in apical part of cell and late endosome. Is expressed in adult head. Orthologous to human CHMP1B (charged multivesicular body protein 1B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (18682895..18684061, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (18675995..18677161, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

The ESCRT-III Protein Chmp1 Regulates Lipid Storage in the Drosophila Fat Body.
Title: The ESCRT-III Protein Chmp1 Regulates Lipid Storage in the Drosophila Fat Body.
Drosophila Chmp1 negatively regulates DER signaling, likely through its role in MVB formation
Title: The Drosophila Chmp1 protein determines wing cell fate through regulation of epidermal growth factor receptor signaling.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in endosome transport via multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome transport via multivesicular body sorting pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in late endosome to vacuole transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vacuolar transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ESCRT III complex	IBA Inferred from Biological aspect of Ancestor more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in multivesicular body	IBA Inferred from Biological aspect of Ancestor more info