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    Sp7 Serine protease 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40918, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sp7provided by FlyBase
    Official Full Name
    Serine protease 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0037515
    Locus tag
    Dmel_CG3066
    See related
    AllianceGenome:FB:FBgn0037515
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-Ryu; CG3066; cSP7; Dmel\CG3066; MP1; MP2; MP2/sp7/PAE1; PAE; PAE1; proPO-AE; Sp 7; SP13; sp7; SP7
    Summary
    Predicted to enable serine-type endopeptidase activity. Involved in defense response to Gram-positive bacterium; melanization defense response; and positive regulation of melanization defense response. Located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sp7 in Genome Data Viewer
    Location:
    84D14-84E1; 3-48 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7759786..7763947)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3585508..3589295)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pyd3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46225

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A signaling protease required for melanization in Drosophila affects resistance and tolerance of infections. Ayres JS, et al. PLoS Biol, 2008 Dec 9. PMID 19071960, Free PMC Article
    2. Two clip-domain serine protease homologs, cSPH35 and cSPH242, act as a cofactor for prophenoloxidase-1 activation in Drosophila melanogaster. Jin Q, et al. Front Immunol, 2023. PMID 37781370, Free PMC Article
    3. Thorax injury lowers resistance to infection in Drosophila melanogaster. Chambers MC, et al. Infect Immun, 2014 Oct. PMID 25092914, Free PMC Article
    4. Amontillado is required for Drosophila Slit processing and for tendon-mediated muscle patterning. Ordan E, et al. Biol Open, 2016 Oct 15. PMID 27628033, Free PMC Article
    5. Serine protease MP2 activates prophenoloxidase in the melanization immune response of Drosophila melanogaster. An C, et al. PLoS One, 2013. PMID 24260243, Free PMC Article

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in melanization defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of melanization defense response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of melanization defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine protease 7
    Names
    CG3066-PA
    CG3066-PE
    CG3066-PF
    Sp7-PA
    Sp7-PE
    Sp7-PF
    melanization protease 2
    prophenoloxidase-activating enzyme
    prophenoloxidase-activating enzyme 1
    serine protease-7
    NP_649734.2
    NP_731174.1
    NP_731175.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7759786..7763947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141477.2 → NP_649734.2  serine protease 7, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649734.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F7VJU2, Q6BD09, Q95SU8, Q9I7L2, Q9V3Z2
      Related
      FBpp0081237, FBtr0081740
      Conserved Domains (3) summary
      smart00020
      Location:136 → 385
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:137 → 388
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam12032
      Location:31 → 84
      CLIP; Regulatory CLIP domain of proteinases

    2. NM_169193.3 → NP_731175.2  serine protease 7, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731175.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F7VJU2, Q6BD09, Q95SU8, Q9I7L2, Q9V3Z2
      Conserved Domains (3) summary
      smart00020
      Location:136 → 385
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:137 → 388
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam12032
      Location:31 → 84
      CLIP; Regulatory CLIP domain of proteinases

    3. NM_169192.3 → NP_731174.1  serine protease 7, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731174.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F7VJU2, Q6BD09, Q95SU8, Q9I7L2, Q9V3Z2
      Related
      FBpp0308321
      Conserved Domains (3) summary
      smart00020
      Location:136 → 385
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:137 → 388
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam12032
      Location:31 → 84
      CLIP; Regulatory CLIP domain of proteinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95SU8 Q95SU8
    Q9V3Z2.1 Q9V3Z2

    Gene LinkOut

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