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    SPH93 Serine protease homolog 93 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35049, updated on 4-Jan-2025

    Summary

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    Official Symbol
    SPH93provided by FlyBase
    Official Full Name
    Serine protease homolog 93provided by FlyBase
    Primary source
    FLYBASE:FBgn0032638
    Locus tag
    Dmel_CG6639
    See related
    AllianceGenome:FB:FBgn0032638
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c-SPH93; CG6639; cSPH93; Dmel\CG6639
    Summary
    Involved in defense response to Gram-positive bacterium. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See SPH93 in Genome Data Viewer
    Location:
    36C9-36C9; 2-53 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17454263..17455923, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17454263..17455923, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene dorsal Neighboring gene long non-coding RNA:CR46204 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Bicaudal D Neighboring gene small glutamine-rich tetratricopeptide containing protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression and regulation of Spätzle-processing enzyme in Drosophila. Mulinari S, et al. FEBS Lett, 2006 Oct 2. PMID 16996061
    2. Dual proteomics of Drosophila melanogaster hemolymph infected with the heritable endosymbiont Spiroplasma poulsonii. Masson F, et al. PLoS One, 2021. PMID 33914801, Free PMC Article
    3. Pathogenesis of listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin. Gordon MD, et al. PLoS Pathog, 2008 Jul 25. PMID 18654628, Free PMC Article
    4. Drosophila immunity: a large-scale in vivo RNAi screen identifies five serine proteases required for Toll activation. Kambris Z, et al. Curr Biol, 2006 Apr 18. PMID 16631589
    5. A comparison of the transcriptome of Drosophila melanogaster in response to entomopathogenic fungus, ionizing radiation, starvation and cold shock. Moskalev A, et al. BMC Genomics, 2015. PMID 26694630, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    NOT enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables serine-type endopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine protease homolog 93
    Names
    CG6639-PA
    SPH93-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      17454263..17455923 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135996.4 → NP_609840.1  serine protease homolog 93 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609840.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJD7
      Related
      FBpp0080557
      Conserved Domains (3) summary
      smart00020
      Location:252 → 482
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:250 → 485
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam07172
      Location:136 → 189
      GRP; Glycine rich protein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJD7 Q9VJD7

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