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    Rexo5 RNA exonuclease 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38740, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rexo5provided by FlyBase
    Official Full Name
    RNA exonuclease 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0286051
    Locus tag
    Dmel_CG8368
    See related
    AllianceGenome:FB:FBgn0286051
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8368; Dmel\CG8368; l(3)65CEa; X
    Summary
    Enables 3'-5'-RNA exonuclease activity. Involved in rRNA 3'-end processing and sno(s)RNA 3'-end processing. Located in nucleolus. Orthologous to human REXO5 (RNA exonuclease 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rexo5 in Genome Data Viewer
    Location:
    65B5-65C1; 3-17 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6603684..6608739)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6596784..6601839)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Mitochondrial calcium uniporter Neighboring gene javelin Neighboring gene nudel Neighboring gene long non-coding RNA:CR45418 Neighboring gene zero population growth Neighboring gene axundead

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila javelin gene encodes a novel actin-associated protein required for actin assembly in the bristle. Shapira S, et al. Mol Cell Biol, 2011 Nov. PMID 21930794, Free PMC Article
    2. drifter, a Drosophila POU-domain transcription factor, is required for correct differentiation and migration of tracheal cells and midline glia. Anderson MG, et al. Genes Dev, 1995 Jan 1. PMID 7828848
    3. A germline-specific gap junction protein required for survival of differentiating early germ cells. Tazuke SI, et al. Development, 2002 May. PMID 11973283
    4. Biogenesis of RNase P RNA from an intron requires co-assembly with cognate protein subunits. Palsule G, et al. Nucleic Acids Res, 2019 Sep 19. PMID 31287870, Free PMC Article
    5. RNA kinase CLP1/Cbc regulates meiosis initiation in spermatogenesis. Wu J, et al. Hum Mol Genet, 2021 Aug 12. PMID 33864361, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss-of-function mutants of Rexo5 accumulate improperly 3' end-trimmed 28S rRNA, 5S rRNA, and snoRNA precursors in vivo.
      Title: The Conserved RNA Exonuclease Rexo5 Is Required for 3' End Maturation of 28S rRNA, 5S rRNA, and snoRNAs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sno(s)RNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA exonuclease 5
    Names
    CG8368-PA
    CG8368-PB
    RNase H-like
    Rexo5-PA
    Rexo5-PB
    distal W5.4 group X
    lethal (3) 65CEa
    NP_648050.1
    NP_729177.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6603684..6608739
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168172.2 → NP_729177.1  RNA exonuclease 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729177.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRX7
      Related
      FBpp0076685
      Conserved Domains (1) summary
      cd06145
      Location:357 → 507
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins

    2. NM_139793.2 → NP_648050.1  RNA exonuclease 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648050.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRX7
      Related
      FBpp0076686
      Conserved Domains (1) summary
      cd06145
      Location:357 → 507
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRX7 Q9VRX7

    Gene LinkOut

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