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    CanA-14F Calcineurin A at 14F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 8674098, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CanA-14Fprovided by FlyBase
    Official Full Name
    Calcineurin A at 14Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267912
    Locus tag
    Dmel_CG9819
    See related
    AllianceGenome:FB:FBgn0267912
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CaN; canA-14F; CaNA-14F; CanA14F; CG9819; CnnA14D; CnnA14D(I); D27; DmCanA-14F; Dmel\CG9819; MRE12; PP2B; PpD27
    Summary
    Enables calmodulin-dependent protein phosphatase activity. Involved in sleep. Predicted to be part of calcineurin complex. Predicted to be active in cytoplasm. Is expressed in adult brain; adult optic lobe; and retina. Human ortholog(s) of this gene implicated in aortic valve stenosis; developmental and epileptic encephalopathy 91; and schizophrenia. Orthologous to several human genes including PPP3CB (protein phosphatase 3 catalytic subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CanA-14F in Genome Data Viewer
    Location:
    14E3-14F1; 1-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16560684..16587172, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16454717..16481205, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Actin-related protein 2 Neighboring gene Protein phosphatase 2B at 14D Neighboring gene uncharacterized protein Neighboring gene Structural maintenance of chromosomes 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reduced Cardiac Calcineurin Expression Mimics Long-Term Hypoxia-Induced Heart Defects in Drosophila. Zarndt R, et al. Circ Cardiovasc Genet, 2017 Oct. PMID 28986453, Free PMC Article
    2. Activation of Ca(2+) phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies. Marchesan E, et al. Cell Death Differ, 2024 Feb. PMID 38238520, Free PMC Article
    3. The calcineurin regulator sra plays an essential role in female meiosis in Drosophila. Takeo S, et al. Curr Biol, 2006 Jul 25. PMID 16860743
    4. Calcineurin and its regulator sra/DSCR1 are essential for sleep in Drosophila. Nakai Y, et al. J Neurosci, 2011 Sep 7. PMID 21900555, Free PMC Article
    5. Pan-neuronal knockdown of calcineurin reduces sleep in the fruit fly, Drosophila melanogaster. Tomita J, et al. J Neurosci, 2011 Sep 14. PMID 21917797, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results indicate a role for Cn and calcium-dependent signal transduction in sleep and memory regulation.
      Title: Pan-neuronal knockdown of calcineurin reduces sleep in the fruit fly, Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcineurin-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcineurin-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sleep IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of calcineurin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calcineurin A at 14F
    Names
    CG9819-PA
    CG9819-PB
    CG9819-PC
    CG9819-PD
    CanA-14F-PA
    CanA-14F-PB
    CanA-14F-PC
    CanA-14F-PD
    calcineurin
    mRNA-like ncRNA in embryogenesis 12
    protein phosphatase D27
    protein phosphatase from PCR fragment D27
    NP_001245717.1
    NP_001259622.1
    NP_727985.2
    NP_727986.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16560684..16587172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258788.2 → NP_001245717.1  calcineurin A at 14F, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245717.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27573, Q86NL0, Q9VXF1
      UniProtKB/TrEMBL
      M9NEL1
      Conserved Domains (2) summary
      smart00156
      Location:132 → 403
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07416
      Location:115 → 419
      MPP_PP2B; PP2B, metallophosphatase domain

    2. NM_167524.3 → NP_727986.2  calcineurin A at 14F, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727986.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27573, Q86NL0, Q9VXF1
      UniProtKB/TrEMBL
      M9NEL1
      Conserved Domains (2) summary
      smart00156
      Location:132 → 403
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07416
      Location:115 → 419
      MPP_PP2B; PP2B, metallophosphatase domain

    3. NM_001272693.2 → NP_001259622.1  calcineurin A at 14F, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259622.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27573, Q86NL0, Q9VXF1
      UniProtKB/TrEMBL
      M9NEL1
      Conserved Domains (2) summary
      smart00156
      Location:132 → 403
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07416
      Location:115 → 419
      MPP_PP2B; PP2B, metallophosphatase domain

    4. NM_167523.3 → NP_727985.2  calcineurin A at 14F, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727985.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27573, Q86NL0, Q9VXF1
      UniProtKB/TrEMBL
      M9NEL1
      Conserved Domains (2) summary
      smart00156
      Location:132 → 403
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07416
      Location:115 → 419
      MPP_PP2B; PP2B, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NEL1 M9NEL1
    Q26249 Q26249
    Q9VXF1.4 Q9VXF1

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