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    exp expansion [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36276, updated on 9-Dec-2024

    Summary

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    Official Symbol
    expprovided by FlyBase
    Official Full Name
    expansionprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033668
    Locus tag
    Dmel_CG13188
    See related
    AllianceGenome:FB:FBgn0033668
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13188; Dmel\CG13188; Exp
    Summary
    Involved in chitin-based embryonic cuticle biosynthetic process and trachea morphogenesis. Located in apical part of cell and cytoplasm. Is active in cytoplasmic side of apical plasma membrane. Is expressed in several structures, including embryonic head epidermis; embryonic ventral epidermis; epithelium; larval tracheal system; and tracheal dorsal trunk primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See exp in Genome Data Viewer
    Location:
    48D3-48D5; 2-65 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11939557..11967435)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7827062..7854940)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44305 Neighboring gene long non-coding RNA:CR44312 Neighboring gene Proteasome inhibitor 31 kDa Neighboring gene ADD domain-containing protein 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deciphering the genetic programme triggering timely and spatially-regulated chitin deposition. Moussian B, et al. PLoS Genet, 2015 Jan. PMID 25617778, Free PMC Article
    2. Structure of the N-terminal domain of the protein Expansion: an 'Expansion' to the Smad MH2 fold. Beich-Frandsen M, et al. Acta Crystallogr D Biol Crystallogr, 2015 Apr. PMID 25849395, Free PMC Article
    3. A dynamic interplay between chitin synthase and the proteins Expansion/Rebuf reveals that chitin polymerisation and translocation are uncoupled in Drosophila. De Giorgio E, et al. PLoS Biol, 2023 Jan. PMID 36689563, Free PMC Article
    4. The novel Smad protein Expansion regulates the receptor tyrosine kinase pathway to control Drosophila tracheal tube size. Iordanou E, et al. Dev Biol, 2014 Sep 1. PMID 24973580, Free PMC Article
    5. DDT resistance in Drosophila correlates with Cyp6g1 over-expression and confers cross-resistance to the neonicotinoid imidacloprid. Daborn P, et al. Mol Genet Genomics, 2001 Dec. PMID 11810226

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A dynamic interplay between chitin synthase and the proteins Expansion/Rebuf reveals that chitin polymerisation and translocation are uncoupled in Drosophila.
      Title: A dynamic interplay between chitin synthase and the proteins Expansion/Rebuf reveals that chitin polymerisation and translocation are uncoupled in Drosophila.
    2. To compare the Expansion and Smad MH2 domains, the crystal structure of the Expansion domain was determined at 1.6 A resolution, the first structure of a non-Smad MH2 domain to be characterized to date.
      Title: Structure of the N-terminal domain of the protein Expansion: an 'Expansion' to the Smad MH2 fold.
    3. This work provides a clear understanding of the role of Expansion, anovel Smad protein, in the regulation of Drosophila tracheal tube diameter.
      Title: The novel Smad protein Expansion regulates the receptor tyrosine kinase pathway to control Drosophila tracheal tube size.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in chitin-based embryonic cuticle biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in trachea morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic side of apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    expansion
    Names
    CG13188-PA
    CG13188-PB
    exp-PA
    exp-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11939557..11967435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165853.2 → NP_725091.1  expansion, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725091.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8R1
      Related
      FBpp0087145
      Conserved Domains (1) summary
      cl00056
      Location:56 → 224
      MH2; C-terminal Mad Homology 2 (MH2) domain

    2. NM_136870.2 → NP_610714.1  expansion, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610714.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8R0, Q7YU38
      Related
      FBpp0087146
      Conserved Domains (1) summary
      cl00056
      Location:56 → 224
      MH2; C-terminal Mad Homology 2 (MH2) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z8R0 A1Z8R0
    A1Z8R1 A1Z8R1
    Q7YU38 Q7YU38

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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