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    Rsu1 Ras suppressor protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 20163, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rsu1provided by MGI
    Official Full Name
    Ras suppressor protein 1provided by MGI
    Primary source
    MGI:MGI:103040
    See related
    Ensembl:ENSMUSG00000026727 AllianceGenome:MGI:103040
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RsuI; rsp-1
    Summary
    Acts upstream of or within Ras protein signal transduction and positive regulation of neural precursor cell proliferation. Predicted to be located in focal adhesion. Is expressed in brain; cerebral cortex ventricular layer; meninges; and telencephalon. Orthologous to human RSU1 (Ras suppressor protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 59.3), subcutaneous fat pad adult (RPKM 30.5) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rsu1 in Genome Data Viewer
    Location:
    2 A1; 2 9.73 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (13081778..13276116, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (13076967..13271438, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene phosphotriesterase related Neighboring gene STARR-seq mESC enhancer starr_03698 Neighboring gene predicted gene, 52597 Neighboring gene C1q-like 3 Neighboring gene STARR-seq mESC enhancer starr_03699 Neighboring gene STARR-positive B cell enhancer ABC_E5887 Neighboring gene STARR-positive B cell enhancer ABC_E1000 Neighboring gene STARR-positive B cell enhancer ABC_E5888 Neighboring gene STARR-seq mESC enhancer starr_03701 Neighboring gene STARR-seq mESC enhancer starr_03702 Neighboring gene predicted gene 13270 Neighboring gene cubilin Neighboring gene predicted gene, 57686

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Human RSU1 is highly homologous to mouse Rsu-1 and localizes to human chromosome 10. Tsuda T, et al. Genomics, 1993 Nov. PMID 8288261
    2. Isolation of rsp-1, a novel cDNA capable of suppressing v-Ras transformation. Cutler ML, et al. Mol Cell Biol, 1992 Sep. PMID 1508180, Free PMC Article
    3. PINCH-1 promotes Bcl-2-dependent survival signalling and inhibits JNK-mediated apoptosis in the primitive endoderm. Montanez E, et al. J Cell Sci, 2012 Nov 1. PMID 22946061
    4. The Ras suppressor Rsu-1 binds to the LIM 5 domain of the adaptor protein PINCH1 and participates in adhesion-related functions. Dougherty GW, et al. Exp Cell Res, 2005 May 15. PMID 15878342
    5. Dissecting integrin-dependent regulation of neural stem cell proliferation in the adult brain. Porcheri C, et al. J Neurosci, 2014 Apr 9. PMID 24719101, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rsu-1 interacts with the LIM 5 domain of PINCH1 in mammalian cells and functions, in part, by altering cell adhesion.
      Title: The Ras suppressor Rsu-1 binds to the LIM 5 domain of the adaptor protein PINCH1 and participates in adhesion-related functions.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of neural precursor cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of neural precursor cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras suppressor protein 1
    Names
    rsu-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420897.1 → NP_001407826.1  ras suppressor protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL928807, AL929209, AL935271

    2. NM_001420898.1 → NP_001407827.1  ras suppressor protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL928807, AL929209, AL935271
      UniProtKB/TrEMBL
      A2AUR7
      Related
      ENSMUSP00000110439.3, ENSMUST00000114791.9

    3. NM_001420899.1 → NP_001407828.1  ras suppressor protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL928807, AL935271
      UniProtKB/TrEMBL
      Q3TFN7
      Related
      ENSMUST00000162223.8

    4. NM_001420900.1 → NP_001407829.1  ras suppressor protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL928807, AL929209, AL935271

    5. NM_001420901.1 → NP_001407830.1  ras suppressor protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL928807, AL929209, AL935271

    6. NM_001420902.1 → NP_001407831.1  ras suppressor protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL928807, AL929209, AL935271

    7. NM_001420903.1 → NP_001407832.1  ras suppressor protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL928807, AL935271
      Related
      ENSMUSP00000117460.2, ENSMUST00000137670.3

    8. NM_001420904.1 → NP_001407833.1  ras suppressor protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL928807, AL935271

    9. NM_001420905.1 → NP_001407834.1  ras suppressor protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL928807

    10. NM_009105.5 → NP_033131.2  ras suppressor protein 1 isoform 1

      See identical proteins and their annotated locations for NP_033131.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL928807, AL929209, AL935271
      Consensus CDS
      CCDS15693.1
      UniProtKB/Swiss-Prot
      Q01730
      UniProtKB/TrEMBL
      Q9D031
      Related
      ENSMUSP00000028059.3, ENSMUST00000028059.9
      Conserved Domains (2) summary
      COG4886
      Location:38 → 202
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:19 → 41
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      13081778..13276116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01730.3 GenPept UniProtKB/Swiss-Prot:Q01730

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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