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    MCRIP1 MAPK regulated corepressor interacting protein 1 [ Homo sapiens (human) ]

    Gene ID: 348262, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MCRIP1provided by HGNC
    Official Full Name
    MAPK regulated corepressor interacting protein 1provided by HGNC
    Primary source
    HGNC:HGNC:28007
    See related
    Ensembl:ENSG00000225663 MIM:616514; AllianceGenome:HGNC:28007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GRAN2; MCRIP; FAM195B
    Summary
    Involved in regulation of epithelial to mesenchymal transition. Located in cytoplasmic stress granule and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 31.8), fat (RPKM 25.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MCRIP1 in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (81822361..81833291, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82689526..82700456, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79780237..79791167, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371929 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79699122-79699658 Neighboring gene uncharacterized LOC105376789 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79761495-79761994 Neighboring gene glucagon receptor Neighboring gene Sharpr-MPRA regulatory region 4607 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:79781934-79782157 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79783828-79784461 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79789117-79789630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79789631-79790144 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79791171-79791684 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79792198-79792710 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79792711-79793223 Neighboring gene protein phosphatase 1 regulatory subunit 27 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79813353-79813852 Neighboring gene prolyl 4-hydroxylase subunit beta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9154

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP. Ichikawa K, et al. Mol Cell, 2015 Apr 2. PMID 25728771
    2. Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins. Bish R, et al. Biomolecules, 2015 Jul 15. PMID 26184334, Free PMC Article
    3. Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells. MacLeod G, et al. Cell Rep, 2019 Apr 16. PMID 30995489
    4. KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II. McNamara RP, et al. Mol Cell, 2016 Jan 7. PMID 26725010, Free PMC Article
    5. Physiological and pathophysiological characteristics of ataxin-3 isoforms. Weishäupl D, et al. J Biol Chem, 2019 Jan 11. PMID 30455355, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP.
      Title: MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC133184, DKFZp686A17165

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of epithelial to mesenchymal transition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mapk-regulated corepressor-interacting protein 1
    Names
    MAPK-regulated co-repressor interacting protein 1
    family with sequence similarity 195, member B
    granulin-2
    protein FAM195B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001093767.3 → NP_001087236.1  mapk-regulated corepressor-interacting protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001087236.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1 and 2 encode the same isoform (2), which is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      BE831904, BX649156
      Consensus CDS
      CCDS45814.1
      UniProtKB/Swiss-Prot
      C9JLW8, Q6ZUL0
      UniProtKB/TrEMBL
      I3L2L5
      Related
      ENSP00000445543.1, ENST00000538396.5
      Conserved Domains (1) summary
      pfam14799
      Location:4 → 89
      FAM195; FAM195 family

    2. NM_001288798.2 → NP_001275727.1  mapk-regulated corepressor-interacting protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001275727.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (1).
      Source sequence(s)
      BC094876, BE831904, BG830426
      Consensus CDS
      CCDS74179.1
      UniProtKB/TrEMBL
      A0A024R8W3, I3L4Q0
      Related
      ENSP00000461433.1, ENST00000572645.5
      Conserved Domains (1) summary
      pfam14799
      Location:25 → 110
      FAM195; FAM195 family

    3. NM_001288799.2 → NP_001275728.1  mapk-regulated corepressor-interacting protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001275728.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences, resulting in different UTRs and translation initiation at a downstream start codon, compared to variant 3. The encoded protein (isoform 3) is shorter than isoform 1.
      Source sequence(s)
      BC063557, BE831904, BG830426, BU188846
      Consensus CDS
      CCDS74178.1
      UniProtKB/TrEMBL
      I3L3A7
      Related
      ENSP00000460299.1, ENST00000573478.5
      Conserved Domains (1) summary
      pfam14799
      Location:4 → 43
      FAM195; FAM195 family

    4. NM_207368.5 → NP_997251.2  mapk-regulated corepressor-interacting protein 1 isoform 2

      See identical proteins and their annotated locations for NP_997251.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the UTRs, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1 and 2 encode the same isoform (2), which is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AK000852, BC094876, BE831904, BG830426
      Consensus CDS
      CCDS45814.1
      UniProtKB/Swiss-Prot
      C9JLW8, Q6ZUL0
      UniProtKB/TrEMBL
      I3L2L5
      Related
      ENSP00000409009.2, ENST00000455127.7
      Conserved Domains (1) summary
      pfam14799
      Location:4 → 89
      FAM195; FAM195 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      81822361..81833291 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435914.1 → XP_047291870.1  mapk-regulated corepressor-interacting protein 1 isoform X3

      UniProtKB/TrEMBL
      I3L3A7

    2. XM_047435913.1 → XP_047291869.1  mapk-regulated corepressor-interacting protein 1 isoform X2

    3. XM_011523572.3 → XP_011521874.1  mapk-regulated corepressor-interacting protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011521874.1

      Conserved Domains (1) summary
      pfam14799
      Location:25 → 76
      FAM195; FAM195 family

    4. XM_011523571.3 → XP_011521873.1  mapk-regulated corepressor-interacting protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011521873.1

      UniProtKB/TrEMBL
      A0A024R8W3, I3L4Q0
      Related
      ENSP00000460461.1, ENST00000575061.2
      Conserved Domains (1) summary
      pfam14799
      Location:25 → 110
      FAM195; FAM195 family

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160021.1 Reference GRCh38.p14 PATCHES

      Range
      35854..46784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332669.1 → XP_054188644.1  mapk-regulated corepressor-interacting protein 1 isoform X3

      UniProtKB/TrEMBL
      I3L3A7

    2. XM_054332668.1 → XP_054188643.1  mapk-regulated corepressor-interacting protein 1 isoform X2

    3. XM_054332667.1 → XP_054188642.1  mapk-regulated corepressor-interacting protein 1 isoform X2

    4. XM_054332666.1 → XP_054188641.1  mapk-regulated corepressor-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A024R8W3, I3L4Q0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      82689526..82700456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315951.1 → XP_054171926.1  mapk-regulated corepressor-interacting protein 1 isoform X3

      UniProtKB/TrEMBL
      I3L3A7

    2. XM_054315950.1 → XP_054171925.1  mapk-regulated corepressor-interacting protein 1 isoform X2

    3. XM_054315949.1 → XP_054171924.1  mapk-regulated corepressor-interacting protein 1 isoform X2

    4. XM_054315948.1 → XP_054171923.1  mapk-regulated corepressor-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A024R8W3, I3L4Q0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C9JLW8.1 GenPept UniProtKB/Swiss-Prot:C9JLW8

    Gene LinkOut

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