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    PF3D7_1343700 kelch protein K13 [ Plasmodium falciparum 3D7 ]

    Gene ID: 814205, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1343700
    Gene description
    kelch protein K13
    Locus tag
    PF3D7_1343700
    See related
    PlasmoDB:PF3D7_1343700; VEuPathDB:PF3D7_1343700
    Gene type
    protein coding
    RNA name
    kelch protein K13
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1343700 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    1
    Sequence:
    Chromosome: 13; NC_004331.3 (1724817..1726997, complement)

    Chromosome 13 - NC_004331.3Genomic Context describing neighboring genes Neighboring gene conserved protein, unknown function Neighboring gene UDP-N-acetylglucosamine pyrophosphorylase, putative Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene U4/U6 small nuclear ribonucleoprotein PRP4, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004331.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Targeted deep amplicon sequencing of kelch 13 and cytochrome b in Plasmodium falciparum isolates from an endemic African country using the Malaria Resistance Surveillance (MaRS) protocol. L'Episcopia M, et al. Parasit Vectors, 2020 Mar 14. PMID 32171330, Free PMC Article
    2. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Ariey F, et al. Nature, 2014 Jan 2. PMID 24352242, Free PMC Article
    3. Emergence of Mutations in the K13 Propeller Gene of Plasmodium falciparum Isolates from Dakar, Senegal, in 2013-2014. Boussaroque A, et al. Antimicrob Agents Chemother, 2016 Jan. PMID 26503652, Free PMC Article
    4. Plasmodium falciparum kelch 13: a potential molecular marker for tackling artemisinin-resistant malaria parasites. Mita T, et al. Expert Rev Anti Infect Ther, 2016. PMID 26535806
    5. Remodeling of the malaria parasite and host human red cell by vesicle amplification that induces artemisinin resistance. Bhattacharjee S, et al. Blood, 2018 Mar 15. PMID 29363540, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An overview of artemisinin-resistant malaria and associated Pfk13 gene mutations in Central Africa.
      Title: An overview of artemisinin-resistant malaria and associated Pfk13 gene mutations in Central Africa.
    2. Molecular characterization of the Plasmodium falciparum k13 gene helix domain in samples from native communities of Condorcanqui, Amazonas, Peru.
      Title: Molecular characterization of the Plasmodium falciparum k13 gene helix domain in samples from native communities of Condorcanqui, Amazonas, Perú.
    3. Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea.
      Title: Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea.
    4. Anti-malarial resistance in Mozambique: Absence of Plasmodium falciparum Kelch 13 (K13) propeller domain polymorphisms associated with resistance to artemisinins.
      Title: Anti-malarial resistance in Mozambique: Absence of Plasmodium falciparum Kelch 13 (K13) propeller domain polymorphisms associated with resistance to artemisinins.
    5. Novel pfk13 polymorphisms in Plasmodium falciparum population in Ghana.
      Title: Novel pfk13 polymorphisms in Plasmodium falciparum population in Ghana.
    6. Mutation in the Plasmodium falciparum BTB/POZ Domain of K13 Protein Confers Artemisinin Resistance.
      Title: Mutation in the Plasmodium falciparum BTB/POZ Domain of K13 Protein Confers Artemisinin Resistance.
    7. Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness.
      Title: Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness.
    8. A review of the frequencies of Plasmodium falciparum Kelch 13 artemisinin resistance mutations in Africa.
      Title: A review of the frequencies of Plasmodium falciparum Kelch 13 artemisinin resistance mutations in Africa.
    9. Molecular surveillance of anti-malarial resistance pfcrt, pfmdr1, and pfk13 polymorphisms in African Plasmodium falciparum imported parasites to Wuhan, China.
      Title: Molecular surveillance of anti-malarial resistance pfcrt, pfmdr1, and pfk13 polymorphisms in African Plasmodium falciparum imported parasites to Wuhan, China.
    10. Molecular surveillance of drug resistance: Plasmodium falciparum artemisinin resistance single nucleotide polymorphisms in Kelch protein propeller (K13) domain from Southern Pakistan.
      Title: Molecular surveillance of drug resistance: Plasmodium falciparum artemisinin resistance single nucleotide polymorphisms in Kelch protein propeller (K13) domain from Southern Pakistan.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kelch protein K13

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004331.3 Reference assembly

      Range
      1724817..1726997 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001350122.1 → XP_001350158.1  kelch protein K13 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001350158.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024WJI1, A0A024X2U1, A0A077LQB1, A0A077LQB4, A0A077LRU9, Q8IDQ2, W4J1T7, W7FG80, W7J7K0, W7JP58
      Conserved Domains (6) summary
      smart00612
      Location:444 → 490
      Kelch; Kelch domain
      PHA03098
      Location:483 → 708
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:481 → 524
      Kelch; KELCH repeat [structural motif]
      cd18316
      Location:352 → 435
      BTB_POZ_KCTD-like; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins
      pfam17380
      Location:230 → 353
      DUF5401; Family of unknown function (DUF5401)
      NF033609
      Location:8 → 93
      MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
    Nucleotide Protein
    Heading Accession and Version

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