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    PF3D7_1445400 protein serine/threonine kinase-1 [ Plasmodium falciparum 3D7 ]

    Gene ID: 812013, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1445400
    Gene description
    protein serine/threonine kinase-1
    Locus tag
    PF3D7_1445400
    See related
    PlasmoDB:PF3D7_1445400; VEuPathDB:PF3D7_1445400
    Gene type
    protein coding
    RNA name
    protein serine/threonine kinase-1
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1445400 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    1
    Sequence:
    Chromosome: 14; NC_037283.1 (1862775..1865420, complement)

    Chromosome 14 - NC_037283.1Genomic Context describing neighboring genes Neighboring gene ATP-dependent RNA helicase MAK5, putative Neighboring gene mitochondrial ribosomal protein S29 precursor, putative Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene RNA-binding protein, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037283.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Primary structure and sexual stage-specific expression of a LAMMER protein kinase of Plasmodium falciparum. Li JL, et al. Int J Parasitol, 2001 Apr. PMID 11306117
    2. Two nucleus-localized CDK-like kinases with crucial roles for malaria parasite erythrocytic replication are involved in phosphorylation of splicing factor. Agarwal S, et al. J Cell Biochem, 2011 May. PMID 21312235
    3. A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, et al. Nature, 2005 Nov 3. PMID 16267556
    4. Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Nature, 2002 Oct 3. PMID 12368864, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these data indicate a crucial role of PfCLK-1 and PfCLK-2 for malaria blood stage parasites, presumably by participating in gene regulation through the post-transcriptional modification of mRNA.
      Title: Two nucleus-localized CDK-like kinases with crucial roles for malaria parasite erythrocytic replication are involved in phosphorylation of splicing factor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables protein serine/threonine/tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein serine/threonine kinase-1
    XP_001348605.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037283.1 Reference assembly

      Range
      1862775..1865420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001348569.1 → XP_001348605.1  protein serine/threonine kinase-1 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001348605.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q8IL19, Q9BKN8, W7JXU9
      Conserved Domains (1) summary
      cd14134
      Location:539 → 874
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
    Nucleotide Protein
    Heading Accession and Version

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