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    Il18bp interleukin 18 binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84388, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Il18bpprovided by RGD
    Official Full Name
    interleukin 18 binding proteinprovided by RGD
    Primary source
    RGD:620042
    See related
    EnsemblRapid:ENSRNOG00000020150 AllianceGenome:RGD:620042
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Igifbp
    Summary
    Predicted to enable interleukin-18 binding activity. Involved in cellular response to hydrogen peroxide; cellular response to tumor necrosis factor; and response to lipopolysaccharide. Located in extracellular space. Human ortholog(s) of this gene implicated in allergic contact dermatitis and myocardial infarction. Orthologous to human IL18BP (interleukin 18 binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 62.9), Heart (RPKM 54.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Il18bp in Genome Data Viewer
    Location:
    1q32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (165784916..165787990, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (156372923..156374963, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (167091521..167095727, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 51 Neighboring gene nuclear mitotic apparatus protein 1 Neighboring gene uncharacterized LOC134483764 Neighboring gene ring finger protein 121 Neighboring gene Xrcc1 N-terminal domain containing 1 Neighboring gene transient receptor potential cation channel subfamily C member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Interleukin-18/interleukin-18 binding protein signaling modulates atherosclerotic lesion development and stability. Mallat Z, et al. Circ Res, 2001 Sep 28. PMID 11577031
    2. Remifentanil Ameliorates Liver Ischemia-Reperfusion Injury Through Inhibition of Interleukin-18 Signaling. Liu X, et al. Transplantation, 2015 Oct. PMID 25919765
    3. Suppressive effects of interleukin-18 on liver function in rat liver allografts. Ono S, et al. J Surg Res, 2012 Jul. PMID 21962809
    4. Circulating concentrations of interleukin-18, interleukin-18 binding protein, and gamma interferon in patients with alcoholic hepatitis. Spahr L, et al. Liver Int, 2004 Dec. PMID 15566508
    5. Plasma levels of interleukin-18 and interleukin-18 binding protein are elevated in patients with chronic liver disease. Ludwiczek O, et al. J Clin Immunol, 2002 Nov. PMID 12462332

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Remifentanil protects the liver against I/R injury by modulating hepatic IL-18/IL-18BP balance and inhibiting IL-18 signaling
      Title: Remifentanil Ameliorates Liver Ischemia-Reperfusion Injury Through Inhibition of Interleukin-18 Signaling.
    2. This protein was isolated, cloned and characterized in cultured COS cells.
      Title: Rat interleukin-18 binding protein: cloning, expression, and characterization.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables interleukin-18 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-18 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T-helper 1 type immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in T-helper 1 type immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interleukin-18-binding protein
    Names
    interferon gamma inducing factor binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053374.2 → NP_445826.2  interleukin-18-binding protein precursor

      See identical proteins and their annotated locations for NP_445826.2

      Status: VALIDATED

      Source sequence(s)
      AA925116, AF154569, CB809932, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I6Z8, Q9JLN2
      Conserved Domains (1) summary
      cl23951
      Location:49 → 171
      Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      165784916..165787990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275803.1 → XP_063131873.1  interleukin-18-binding protein isoform X2

    2. XM_008759805.4 → XP_008758027.1  interleukin-18-binding protein isoform X1

      UniProtKB/TrEMBL
      F7F5P4, Q9JLN2
      Related
      ENSRNOP00000027301.3, ENSRNOT00000027301.5
      Conserved Domains (1) summary
      cl23951
      Location:49 → 166
      Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

    RNA

    1. XR_010058350.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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