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    Gpr4 G protein-coupled receptor 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308408, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr4provided by RGD
    Official Full Name
    G protein-coupled receptor 4provided by RGD
    Primary source
    RGD:1311604
    See related
    EnsemblRapid:ENSRNOG00000016362 AllianceGenome:RGD:1311604
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of Rho protein signal transduction; and response to acidic pH. Predicted to act upstream of or within G protein-coupled receptor signaling pathway; blood vessel development; and negative regulation of angiogenesis. Predicted to be active in plasma membrane. Orthologous to human GPR4 (G protein-coupled receptor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 15.7), Lung (RPKM 12.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpr4 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (87993398..88004568)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (78865376..78877126)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (80125639..80136786)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene gastric inhibitory polypeptide receptor Neighboring gene EMAP like 2 Neighboring gene microRNA 330 Neighboring gene outer mitochondrial membrane lipid metabolism regulator OPA3 Neighboring gene vasodilator-stimulated phosphoprotein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Involvement of the G-Protein-Coupled Receptor 4 in the Increased Expression of RANK/RANKL/OPG System and Neurotrophins by Nucleus Pulposus Cells under the Degenerated Intervertebral Disc-Like Acidic Microenvironment. Li H, et al. Biomed Res Int, 2020. PMID 32566653, Free PMC Article
    2. Involvement of GPR4 in increased growth hormone and prolactin expressions by extracellular acidification in MtT/S cells. Musha S, et al. J Reprod Dev, 2020 Apr 10. PMID 31956173, Free PMC Article
    3. Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways. Liu JP, et al. Pharmacol Res, 2010 Jun. PMID 20211729
    4. Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms. Tobo M, et al. Cell Signal, 2007 Aug. PMID 17462861
    5. Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor. Yang LV, et al. Mol Cell Biol, 2007 Feb. PMID 17145776, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interference with GPR4 inactivates NLRP3 inflammasome signaling by inhibiting LPAR1 expression to ameliorate oxygen-glucose deprivation/reoxygenation-induced inflammation and apoptosis of cardiomyocytes.
      Title: Interference with GPR4 inactivates NLRP3 inflammasome signaling by inhibiting LPAR1 expression to ameliorate oxygen-glucose deprivation/reoxygenation-induced inflammation and apoptosis of cardiomyocytes.
    2. Involvement of the G-Protein-Coupled Receptor 4 in the Increased Expression of RANK/RANKL/OPG System and Neurotrophins by Nucleus Pulposus Cells under the Degenerated Intervertebral Disc-Like Acidic Microenvironment.
      Title: Involvement of the G-Protein-Coupled Receptor 4 in the Increased Expression of RANK/RANKL/OPG System and Neurotrophins by Nucleus Pulposus Cells under the Degenerated Intervertebral Disc-Like Acidic Microenvironment.
    3. Involvement of GPR4 in increased growth hormone and prolactin expressions by extracellular acidification in MtT/S cells.
      Title: Involvement of GPR4 in increased growth hormone and prolactin expressions by extracellular acidification in MtT/S cells.
    4. Results indicate that GPR4 is expressed by multiple neuronal populations and endothelium and that its pH sensitivity is affected by level of expression and l-lactic acid (LL). GPR4 antagonist NE 52-QQ57 blunts hypercapnic response to CO2 but this effect is absent under anaesthesia, possibly due to the inhibitory effect of LL on GPR4.
      Title: CNS distribution, signalling properties and central effects of G-protein coupled receptor 4.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116369

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within angiogenesis involved in wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glomerular mesangial cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of vascular permeability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of vascular permeability ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within response to acidic pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to acidic pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to acidic pH ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025680.1 → NP_001020851.1  G-protein coupled receptor 4

      See identical proteins and their annotated locations for NP_001020851.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099196
      UniProtKB/Swiss-Prot
      Q4KLH9
      UniProtKB/TrEMBL
      A6J8L2
      Conserved Domains (1) summary
      cd15366
      Location:20 → 299
      7tmA_GPR4; proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      87993398..88004568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228418.3 → XP_006228480.1  G-protein coupled receptor 4 isoform X1

      See identical proteins and their annotated locations for XP_006228480.1

      UniProtKB/Swiss-Prot
      Q4KLH9
      UniProtKB/TrEMBL
      A6J8L2
      Related
      ENSRNOP00000101552.1, ENSRNOT00000153217.1
      Conserved Domains (1) summary
      cd15366
      Location:20 → 299
      7tmA_GPR4; proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KLH9.1 GenPept UniProtKB/Swiss-Prot:Q4KLH9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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