Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chchd10provided by MGI
Official Full Name: coiled-coil-helix-coiled-coil-helix domain containing 10provided by MGI
Primary source: MGI:MGI:2143558
See related: Ensembl:ENSMUSG00000049422 AllianceGenome:MGI:2143558
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ndg2; 1620401E04Rik
Summary: Predicted to be involved in several processes, including mitochondrial nucleoid organization; oxidative phosphorylation; and regulation of mitochondrion organization. Located in mitochondrion. Is expressed in several structures, including brain ventricle and choroid plexus; early embryo; hypothalamus mantle layer; renal calyx; and ventral grey horn. Used to study isolated mitochondrial myopathy. Human ortholog(s) of this gene implicated in frontotemporal dementia and/or amyotrophic lateral sclerosis 2; isolated mitochondrial myopathy; and spinal muscular atrophy, Jokela type. Orthologous to human CHCHD10 (coiled-coil-helix-coiled-coil-helix domain containing 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in adrenal adult (RPKM 1343.9), duodenum adult (RPKM 646.7) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 38.62 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (75768964..75773584)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (75933130..75937750)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitochondrial protein CHCHD10 inhibits NDV replication and reduces pathological changes.
Title: Mitochondrial protein CHCHD10 inhibits NDV replication and reduces pathological changes.
CHCHD10 mutations induce tissue-specific mitochondrial DNA deletions with a distinct signature.
Title: CHCHD10 mutations induce tissue-specific mitochondrial DNA deletions with a distinct signature.
Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy.
Title: Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy.
Loss of mitochondrial protein CHCHD10 in skeletal muscle causes neuromuscular junction impairment.
Title: Loss of mitochondrial protein CHCHD10 in skeletal muscle causes neuromuscular junction impairment.
Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations.
Title: Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations.
CHCHD10 is highly expressed in the neuromuscular junction post-synaptic part
Title: Mitochondrial defect in muscle precedes neuromuscular junction degeneration and motor neuron death in CHCHD10(S59L/+) mouse.
In the presence of HA1004, NBRE binding by Nur77 protein increases with time (6 h vs 2 h), whereas the final outcome of both inhibitors is apoptosis of thymic lymphoma cells.
Title: Nur77 nuclear import and its NBRE-binding activity in thymic lymphoma cells are regulated by different mechanisms sensitive to FK506 or HA1004.
Nur77 gene knockout alters dopamine neuron biochemical activity and dopamine turnover.
Title: Nur77 gene knockout alters dopamine neuron biochemical activity and dopamine turnover.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (12) 1 citation
Targeted (2) 1 citation

General gene information

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Markers

AI267078 (e-PCR)
- UniSTS:180064

NoName (e-PCR)
- UniSTS:236392

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in mitochondrial nucleoid organization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in oxidative phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cristae formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of MICOS complex	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

Names: Nur77 downstream gene 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175329.4 → NP_780538.2 coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

See identical proteins and their annotated locations for NP_780538.2

Status: VALIDATED

Source sequence(s)

BC083357, BM934773, W16247

Consensus CDS

CCDS23938.1

UniProtKB/TrEMBL

Q7TNL9, Q8BW15

Related

ENSMUSP00000151675.2, ENSMUST00000219839.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

75768964..75773584

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155455.1 → XP_036011348.1 coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1

UniProtKB/TrEMBL

Q7TNL9, Q8BW15

Related

ENSMUSP00000059575.7, ENSMUST00000058906.7