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    Anks1 ankyrin repeat and SAM domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 224650, updated on 27-Nov-2024

    Summary

    Official Symbol
    Anks1provided by MGI
    Official Full Name
    ankyrin repeat and SAM domain containing 1provided by MGI
    Primary source
    MGI:MGI:2446180
    See related
    Ensembl:ENSMUSG00000024219 AllianceGenome:MGI:2446180
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Anks1a; mKIAA0229
    Summary
    Enables ephrin receptor binding activity. Involved in ephrin receptor signaling pathway; neuron remodeling; and substrate-dependent cell migration. Acts upstream of or within negative regulation of ubiquitin-dependent protein catabolic process and regulation of ephrin receptor signaling pathway. Located in neuron projection. Is expressed in several structures, including genitourinary system; gut gland; nervous system; olfactory epithelium; and trachea. Orthologous to human ANKS1A (ankyrin repeat and sterile alpha motif domain containing 1A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 18.8), thymus adult (RPKM 17.2) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Anks1 in Genome Data Viewer
    Location:
    17 A3.3; 17 14.6 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28128273..28281753)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (27909304..28062779)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27976840-27977098 Neighboring gene U1 small nuclear ribonucleoprotein C Neighboring gene bridge-like lipid transfer protein family member 3A Neighboring gene STARR-positive B cell enhancer ABC_E7504 Neighboring gene TATA-box binding protein associated factor 11 Neighboring gene STARR-seq mESC enhancer starr_42177 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28144121-28144327 Neighboring gene predicted gene, 35290 Neighboring gene tRNA splicing endonuclease 34 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42185 Neighboring gene STARR-positive B cell enhancer ABC_E4199 Neighboring gene t-complex protein 11 Neighboring gene VISTA enhancer mm1525 Neighboring gene signal peptide, CUB domain, EGF-like 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (2) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC59413

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ephrin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ephrin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ankyrin repeat and SAM domain-containing protein 1A
    Names
    Odin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286040.1NP_001272969.1  ankyrin repeat and SAM domain-containing protein 1A isoform 1

      See identical proteins and their annotated locations for NP_001272969.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC126040, AC132460, AK147273
      Consensus CDS
      CCDS70777.1
      UniProtKB/TrEMBL
      Q3UHP6
      Related
      ENSMUSP00000025058.8, ENSMUST00000025058.15
      Conserved Domains (7) summary
      cd09499
      Location:713779
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:784848
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      smart00454
      Location:716775
      SAM; Sterile alpha motif
      cd00204
      Location:70219
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01274
      Location:9421087
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      pfam12796
      Location:203294
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:165196
      ANK; ANK repeat [structural motif]
    2. NM_001286041.1NP_001272970.1  ankyrin repeat and SAM domain-containing protein 1A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC126040, AC132460
      Consensus CDS
      CCDS70778.1
      UniProtKB/Swiss-Prot
      P59672
      Related
      ENSMUSP00000085344.6, ENSMUST00000088027.7
      Conserved Domains (7) summary
      cd09499
      Location:692758
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:763827
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      smart00454
      Location:695754
      SAM; Sterile alpha motif
      cd00204
      Location:70198
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01274
      Location:9211066
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      pfam12796
      Location:80175
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:76106
      ANK; ANK repeat [structural motif]
    3. NM_001374802.1NP_001361731.1  ankyrin repeat and SAM domain-containing protein 1A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC126040, AC132460
      Consensus CDS
      CCDS89037.1
      UniProtKB/TrEMBL
      A0A3B2WAQ7
      Related
      ENSMUSP00000156466.2, ENSMUST00000233525.2
      Conserved Domains (5) summary
      cd09499
      Location:692758
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:763827
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      PHA03095
      Location:66280
      PHA03095; ankyrin-like protein; Provisional
      cd01274
      Location:9211066
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      sd00045
      Location:76106
      ANK; ANK repeat [structural motif]
    4. NM_001425247.1NP_001412176.1  ankyrin repeat and SAM domain-containing protein 1A isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC126040, AC132460
    5. NM_181413.4NP_852078.1  ankyrin repeat and SAM domain-containing protein 1A isoform 3

      See identical proteins and their annotated locations for NP_852078.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) use an alternate structure at the 3' end which results in a frameshift compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 2.
      Source sequence(s)
      AC126040, AC132460
      Consensus CDS
      CCDS37525.1
      UniProtKB/Swiss-Prot
      P59672, Q6ZQG0
      Related
      ENSMUSP00000110491.2, ENSMUST00000114842.9
      Conserved Domains (7) summary
      cd09499
      Location:713779
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:784848
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      smart00454
      Location:716775
      SAM; Sterile alpha motif
      cd00204
      Location:70219
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01274
      Location:9421087
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      pfam12796
      Location:203294
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:165196
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      28128273..28281753
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524087.3XP_006524150.1  ankyrin repeat and SAM domain-containing protein 1A isoform X1

      See identical proteins and their annotated locations for XP_006524150.1

      Conserved Domains (6) summary
      cd09499
      Location:713779
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:784848
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      PHA03095
      Location:66301
      PHA03095; ankyrin-like protein; Provisional
      cd01274
      Location:9421087
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      sd00045
      Location:165196
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:203294
      Ank_2; Ankyrin repeats (3 copies)
    2. XM_006524088.3XP_006524151.1  ankyrin repeat and SAM domain-containing protein 1A isoform X2

      See identical proteins and their annotated locations for XP_006524151.1

      Conserved Domains (6) summary
      cd09499
      Location:713779
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:784848
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      PHA03095
      Location:66301
      PHA03095; ankyrin-like protein; Provisional
      cd01274
      Location:9421087
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      sd00045
      Location:165196
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:203294
      Ank_2; Ankyrin repeats (3 copies)
    3. XM_030249683.2XP_030105543.1  ankyrin repeat and SAM domain-containing protein 1A isoform X3

      Conserved Domains (6) summary
      cd09499
      Location:674740
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:745809
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      PHA03095
      Location:27262
      PHA03095; ankyrin-like protein; Provisional
      cd01274
      Location:9031048
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      sd00045
      Location:126157
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:164255
      Ank_2; Ankyrin repeats (3 copies)
    4. XM_030249682.1XP_030105542.1  ankyrin repeat and SAM domain-containing protein 1A isoform X3

      Conserved Domains (6) summary
      cd09499
      Location:674740
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:745809
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      PHA03095
      Location:27262
      PHA03095; ankyrin-like protein; Provisional
      cd01274
      Location:9031048
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      sd00045
      Location:126157
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:164255
      Ank_2; Ankyrin repeats (3 copies)
    5. XM_030249685.1XP_030105545.1  ankyrin repeat and SAM domain-containing protein 1A isoform X5

      Conserved Domains (6) summary
      cd09499
      Location:651717
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:722786
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      PHA03095
      Location:4239
      PHA03095; ankyrin-like protein; Provisional
      cd01274
      Location:8801025
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      sd00045
      Location:103134
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:141232
      Ank_2; Ankyrin repeats (3 copies)
    6. XM_006524089.5XP_006524152.1  ankyrin repeat and SAM domain-containing protein 1A isoform X3

      See identical proteins and their annotated locations for XP_006524152.1

      Conserved Domains (6) summary
      cd09499
      Location:674740
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:745809
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      PHA03095
      Location:27262
      PHA03095; ankyrin-like protein; Provisional
      cd01274
      Location:9031048
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      sd00045
      Location:126157
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:164255
      Ank_2; Ankyrin repeats (3 copies)
    7. XM_030249686.2XP_030105546.1  ankyrin repeat and SAM domain-containing protein 1A isoform X8

      UniProtKB/TrEMBL
      A0A3B2W7H4, Q3TE53
      Conserved Domains (3) summary
      cd09499
      Location:156222
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:227291
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      cd01274
      Location:385530
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
    8. XM_036160515.1XP_036016408.1  ankyrin repeat and SAM domain-containing protein 1A isoform X6

      Conserved Domains (3) summary
      cd09499
      Location:156222
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:227291
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      cd01274
      Location:385530
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
    9. XM_036160516.1XP_036016409.1  ankyrin repeat and SAM domain-containing protein 1A isoform X7

      UniProtKB/TrEMBL
      Q3TE53
      Conserved Domains (3) summary
      cd09499
      Location:156222
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:227291
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      cd01274
      Location:385530
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
    10. XM_006524091.4XP_006524154.1  ankyrin repeat and SAM domain-containing protein 1A isoform X8

      See identical proteins and their annotated locations for XP_006524154.1

      UniProtKB/TrEMBL
      A0A3B2W7H4, Q3TE53
      Related
      ENSMUSP00000156518.2, ENSMUST00000139173.3
      Conserved Domains (3) summary
      cd09499
      Location:156222
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:227291
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      cd01274
      Location:385530
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
    11. XM_036160517.1XP_036016410.1  ankyrin repeat and SAM domain-containing protein 1A isoform X7

      UniProtKB/TrEMBL
      Q3TE53
      Conserved Domains (3) summary
      cd09499
      Location:156222
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:227291
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      cd01274
      Location:385530
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
    12. XM_030249687.2XP_030105547.1  ankyrin repeat and SAM domain-containing protein 1A isoform X10

      UniProtKB/TrEMBL
      A0A3B2W4H6
      Conserved Domains (3) summary
      cd09500
      Location:36100
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      cd01274
      Location:194339
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
      cl15755
      Location:131
      SAM_superfamily; SAM (Sterile alpha motif )
    13. XM_036160518.1XP_036016411.1  ankyrin repeat and SAM domain-containing protein 1A isoform X9

      UniProtKB/TrEMBL
      A0A3B2W4H6
      Related
      ENSMUSP00000156946.2, ENSMUST00000232872.2
      Conserved Domains (3) summary
      cd09499
      Location:1783
      SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
      cd09500
      Location:88152
      SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
      cd01274
      Location:246391
      PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain