Lrrtm2 leucine rich repeat transmembrane neuronal 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrrtm2provided by MGI
Official Full Name: leucine rich repeat transmembrane neuronal 2provided by MGI
Primary source: MGI:MGI:2389174
See related: Ensembl:ENSMUSG00000071862 AllianceGenome:MGI:2389174
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0416; C630011A14Rik
Summary: Predicted to enable neurexin family protein binding activity. Acts upstream of or within several processes, including long-term synaptic potentiation; negative regulation of receptor internalization; and positive regulation of synapse assembly. Predicted to be located in excitatory synapse and membrane. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density membrane. Is expressed in neural tube and neural tube lateral wall. Orthologous to human LRRTM2 (leucine rich repeat transmembrane neuronal 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cortex adult (RPKM 3.7), frontal lobe adult (RPKM 3.2) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B1; 18 18.94 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (35342056..35348077, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (35209003..35215024, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits.
Title: Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits.
The Nrxn1beta-LRRTM2 interface involves Ca(2+)-mediated interactions and overlaps with the Nrxn-neuroligin interface.
Title: Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction.
Genetic deletion of LRRTM1,2 in vivo in CA1 neurons using Cre recombinase-expressing lentiviruses dramatically impaired long-term potentiation (LTP), an impairment that was rescued by simultaneous expression of LRRTM2, but not LRRTM4.
Title: Deletion of LRRTM1 and LRRTM2 in adult mice impairs basal AMPA receptor transmission and LTP in hippocampal CA1 pyramidal neurons.
The crystal structure of a thermostabilized LRRTM2 protein was determined.
Title: Crystal Structure of an Engineered LRRTM2 Synaptic Adhesion Molecule and a Model for Neurexin Binding.
Data indicate that neural Cell Adhesion Molecules Lrrtm1 and Lrrtm2 mRNA expression is controlled by synaptic activity and nuclear calcium signaling.
Title: Nuclear calcium signaling induces expression of the synaptic organizers Lrrtm1 and Lrrtm2.
This study demonistrated that LRRTM2 is essential for maintenance of long-term potentiation in mice hippocampus.
Title: Leucine-rich repeat transmembrane proteins are essential for maintenance of long-term potentiation.
The LRRTM2 acts redundantly to maintain excitatory synapses and that synapse elimination caused by the absence of LRRTM2 is promoted by synaptic activity and mediated by a postsynaptic Ca(2+)/CaM-dependent signaling pathway.
Title: Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB129880 (e-PCR)
- UniSTS:186127

Lrrtm2 (e-PCR), detects polymorphism
- UniSTS:498491

Lrrtm2 (e-PCR), detects polymorphism
- UniSTS:498492

AI851755 (e-PCR)
- UniSTS:181091

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables neurexin family protein binding	IEA Inferred from Electronic Annotation more info
enables neurexin family protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within long-term synaptic potentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of receptor internalization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic density assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic density assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synapse organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within synapse organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in excitatory synapse	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in hippocampal mossy fiber to CA3 synapse	IEA Inferred from Electronic Annotation more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leucine-rich repeat transmembrane neuronal protein 2

Names: leucine-rich repeat transmembrane neuronal 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178005.4 → NP_821072.1 leucine-rich repeat transmembrane neuronal protein 2 precursor

See identical proteins and their annotated locations for NP_821072.1

Status: VALIDATED

Source sequence(s)

AC121874, AK046774

Consensus CDS

CCDS50251.1

UniProtKB/Swiss-Prot

Q80U08, Q8BGA3

UniProtKB/TrEMBL

Q8C8L1

Related

ENSMUSP00000089225.4, ENSMUST00000091636.5

Conserved Domains (3) summary

TIGR00864
Location:284 → 351

PCC; polycystin cation channel protein

COG4886
Location:65 → 312

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:66 → 86

LRR_RI; leucine-rich repeat [structural motif]