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    Ddx18 DEAD box helicase 18 [ Mus musculus (house mouse) ]

    Gene ID: 66942, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ddx18provided by MGI
    Official Full Name
    DEAD box helicase 18provided by MGI
    Primary source
    MGI:MGI:1914192
    See related
    Ensembl:ENSMUSG00000001674 AllianceGenome:MGI:1914192
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310005B10Rik
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and ATP-dependent activity, acting on DNA. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in chromosome. Predicted to be active in nucleolus. Orthologous to human DDX18 (DEAD-box helicase 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 25.0), liver E14 (RPKM 19.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ddx18 in Genome Data Viewer
    Location:
    1 E2.3; 1 52.98 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (121481564..121495709, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (121553835..121567980, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10030 Neighboring gene coiled-coil domain containing 93 Neighboring gene STARR-seq mESC enhancer starr_02076 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 5B Neighboring gene STARR-seq mESC enhancer starr_02077 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:123504681-123504864 Neighboring gene STARR-seq mESC enhancer starr_02078 Neighboring gene STARR-seq mESC enhancer starr_02080 Neighboring gene STARR-seq mESC enhancer starr_02081 Neighboring gene STARR-seq mESC enhancer starr_02082 Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 10 pseudogene Neighboring gene guanosine diphosphate (GDP) dissociation inhibitor 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation. Zhang H, et al. Cell Rep, 2020 Jan 7. PMID 31914400
    2. BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs. Mathew R, et al. Nature, 2012 Nov 22. PMID 23086144, Free PMC Article
    3. PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts. Cairo S, et al. Oncogene, 2005 Mar 24. PMID 15735755
    4. Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression. Borgal L, et al. Cell Cycle, 2016. PMID 26919559, Free PMC Article
    5. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Grebien F, et al. Nat Chem Biol, 2015 Aug. PMID 26167872, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation.
      Title: DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117904

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase DDX18
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
    DEAD box protein 18
    NP_080136.2
    XP_006529857.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025860.3 → NP_080136.2  ATP-dependent RNA helicase DDX18

      See identical proteins and their annotated locations for NP_080136.2

      Status: VALIDATED

      Source sequence(s)
      BC103776, BY084565, BY381480
      Consensus CDS
      CCDS15240.1
      UniProtKB/Swiss-Prot
      Q3MIB0, Q8BVZ2, Q8K363, Q9D2E0
      UniProtKB/TrEMBL
      B2RUM8
      Related
      ENSMUSP00000001724.6, ENSMUST00000001724.12
      Conserved Domains (5) summary
      smart00487
      Location:184 → 372
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:390 → 519
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:169 → 376
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam05177
      Location:50 → 157
      RCSD; RCSD region
      pfam13959
      Location:551 → 609
      DUF4217; Domain of unknown function (DUF4217)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      121481564..121495709 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529794.5 → XP_006529857.1  ATP-dependent RNA helicase DDX18 isoform X1

      Conserved Domains (2) summary
      COG0513
      Location:95 → 508
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd17942
      Location:108 → 305
      DEADc_DDX18; DEAD-box helicase domain of DEAD box protein 18
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K363.1 GenPept UniProtKB/Swiss-Prot:Q8K363

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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