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    Cox4i1 cytochrome c oxidase subunit 4I1 [ Mus musculus (house mouse) ]

    Gene ID: 12857, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Cox4i1provided by MGI
    Official Full Name
    cytochrome c oxidase subunit 4I1provided by MGI
    Primary source
    MGI:MGI:88473
    See related
    Ensembl:ENSMUSG00000031818 AllianceGenome:MGI:88473
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    COX; Cox4; IV-1; COXIV; Cox4a; COX IV-1
    Summary
    Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in cytosol and mitochondrial membrane. Part of respiratory chain complex IV. Is active in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 16. Orthologous to human COX4I1 (cytochrome c oxidase subunit 4I1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 1297.8), kidney adult (RPKM 1026.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cox4i1 in Genome Data Viewer
    Location:
    8 E1; 8 69.99 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (121394964..121400948)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (120668225..120674209)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1190005I06 gene Neighboring gene predicted gene, 27021 Neighboring gene STARR-seq mESC enhancer starr_22909 Neighboring gene predicted gene, 33075 Neighboring gene ER membrane protein complex subunit 8 Neighboring gene predicted gene, 39265 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:123225678-123225981 Neighboring gene STARR-positive B cell enhancer ABC_E6694 Neighboring gene mitochondrial ribosomal protein L30 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of the mouse cytochrome c oxidase subunit IV gene. Carter RS, et al. Arch Biochem Biophys, 1991 Jul. PMID 1654830
    2. Decreased cytochrome c oxidase IV expression reduces steroidogenesis. Pawlak KJ, et al. J Pharmacol Exp Ther, 2011 Aug. PMID 21558439, Free PMC Article
    3. Sex- and brain region-specific role of cytochrome c oxidase in 1-methyl-4-phenylpyridinium-mediated astrocyte vulnerability. Sundar Boyalla S, et al. J Neurosci Res, 2011 Dec. PMID 21598289
    4. Nucleotide sequence of a mouse cDNA for subunit IV of cytochrome c oxidase. Grossman LI, et al. Nucleic Acids Res, 1990 Nov 11. PMID 2173832, Free PMC Article
    5. Male obesity is associated with changed spermatozoa Cox4i1 mRNA level and altered seminal vesicle fluid composition in a mouse model. Binder NK, et al. Mol Hum Reprod, 2015 May. PMID 25731709

    See all (114) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Destabilizing COXIV in Muller Glia Increases Retinal Glycolysis and Alters Scotopic Electroretinogram.
      Title: Destabilizing COXIV in Müller Glia Increases Retinal Glycolysis and Alters Scotopic Electroretinogram.
    2. MicroRNA-338 inhibition protects against focal cerebral ischemia and preserves mitochondrial function in vitro in astrocytes and neurons via COX4I1.
      Title: MicroRNA-338 inhibition protects against focal cerebral ischemia and preserves mitochondrial function in vitro in astrocytes and neurons via COX4I1.
    3. DDIT3 Directs a Dual Mechanism to Balance Glycolysis and Oxidative Phosphorylation during Glutamine Deprivation.
      Title: DDIT3 Directs a Dual Mechanism to Balance Glycolysis and Oxidative Phosphorylation during Glutamine Deprivation.
    4. The authors discovered that the dissociation of the Dynll1-Cox4i1 complex is required for the release of mitochondrial reactive oxygen species and serves as a regulator of intracellular proliferation of Listeria monocytogenes. The study shows that Dynll1 is an inhibitor of mitochondrial reactive oxygen species.
      Title: The Dynll1-Cox4i1 Complex Regulates Intracellular Pathogen Clearance via Release of Mitochondrial Reactive Oxygen Species.
    5. exercise training caused an increase in mRNA and protein levels of COXIV, whereas NAC intervention lowered the two so significantly that even exercise training could not reverse the effect of NAC intervention
      Title: The effect of treadmill training and N-acetyl-l-cysteine intervention on biogenesis of cytochrome c oxidase (COX).
    6. Data suggest that that obesity affects both sperm and seminal plasma composition; Cox4i1 mRNA is up-regulated in spermatozoa of obese mice compared to control mice.
      Title: Male obesity is associated with changed spermatozoa Cox4i1 mRNA level and altered seminal vesicle fluid composition in a mouse model.
    7. Our data suggest that MPP(+) acts on astrocytes in a sex- and brain region-specific manner involving cytochrome c oxidase isoform expression in an impairment of energy production and elevated oxidative stress levels
      Title: Sex- and brain region-specific role of cytochrome c oxidase in 1-methyl-4-phenylpyridinium-mediated astrocyte vulnerability.
    8. Knockdown of small interfering RNA-mediated COX subunit IV decreases progesterone synthesis in steroidogenic cells.
      Title: Decreased cytochrome c oxidase IV expression reduces steroidogenesis.
    9. Under conditions of reduced oxygen availability, hypoxia-inducible factor 1 reciprocally regulates COX4 subunit expression by activating transcription of the genes encoding COX4-2 and LON, a mitochondrial protease that is required for COX4-1 degradation.
      Title: HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex IV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex IV ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 4 isoform 1, mitochondrial
    Names
    cytochrome c oxidase polypeptide IV
    cytochrome c oxidase subunit IV
    cytochrome c oxidase, subunit IVa
    NP_001280488.1
    NP_034071.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293559.1 → NP_001280488.1  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001280488.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK019276, AV469576, BE992841
      Consensus CDS
      CCDS40498.1
      UniProtKB/Swiss-Prot
      P19783, Q545A9
      UniProtKB/TrEMBL
      A2RSV8
      Related
      ENSMUSP00000138019.2, ENSMUST00000181586.8
      Conserved Domains (1) summary
      pfam02936
      Location:36 → 168
      COX4; Cytochrome c oxidase subunit IV

    2. NM_009941.3 → NP_034071.2  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK012583, BE992841, BY250039
      UniProtKB/Swiss-Prot
      P19783
      Conserved Domains (1) summary
      pfam02936
      Location:73 → 205
      COX4; Cytochrome c oxidase subunit IV

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      121394964..121400948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19783.2 GenPept UniProtKB/Swiss-Prot:P19783

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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