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    Sftpd surfactant associated protein D [ Mus musculus (house mouse) ]

    Gene ID: 20390, updated on 13-Jan-2025

    Summary

    Official Symbol
    Sftpdprovided by MGI
    Official Full Name
    surfactant associated protein Dprovided by MGI
    Primary source
    MGI:MGI:109515
    See related
    Ensembl:ENSMUSG00000021795 AllianceGenome:MGI:109515
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SP-D; Sfpd; PSP-D; Sftp4
    Summary
    Enables identical protein binding activity. Predicted to be involved in several processes, including negative regulation of interleukin-2 production; opsonization; and regulation of phagocytosis. Located in cytoplasm. Is expressed in epidermis spinous layer; lung; lung surfactant; otic capsule; and skeleton. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Orthologous to human SFTPD (surfactant protein D). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward lung adult (RPKM 105.6) See more
    Orthologs
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    Genomic context

    See Sftpd in Genome Data Viewer
    Location:
    14 B; 14 22.36 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (40894169..40907155, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (41172212..41185198, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family F (with FYVE domain) member 2 pseudogene Neighboring gene mannose-binding lectin (protein A) 1 Neighboring gene STARR-seq mESC enhancer starr_36478 Neighboring gene predicted gene, 31895 Neighboring gene predicted gene, 22823

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding  
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables lipopolysaccharide binding  
    enables monosaccharide binding  
    Process Evidence Code Pubs
    involved_in innate immune response  
    involved_in lung alveolus development  
    involved_in lung alveolus development  
    involved_in negative regulation of T cell proliferation  
    involved_in negative regulation of interleukin-2 production  
    involved_in negative regulation of phagocytosis  
    involved_in opsonization  
    involved_in positive regulation of phagocytosis  
    involved_in positive regulation of phagocytosis  
    involved_in respiratory gaseous exchange by respiratory system  
    involved_in surfactant homeostasis  
    involved_in surfactant homeostasis  
    involved_in surfactant homeostasis  
    Component Evidence Code Pubs
    part_of collagen trimer  
    located_in collagen-containing extracellular matrix PubMed 
    located_in cytoplasm PubMed 
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space  
    is_active_in multivesicular body  
    located_in multivesicular body  

    General protein information

    Preferred Names
    pulmonary surfactant-associated protein D
    Names
    lung surfactant protein D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009160.2NP_033186.1  pulmonary surfactant-associated protein D precursor

      See identical proteins and their annotated locations for NP_033186.1

      Status: VALIDATED

      Source sequence(s)
      AC124400, AI573415, BG085186, BY116790, CJ237327
      Consensus CDS
      CCDS26962.1
      UniProtKB/Swiss-Prot
      P50404
      Related
      ENSMUSP00000076383.4, ENSMUST00000077136.5
      Conserved Domains (3) summary
      cd03591
      Location:261374
      CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
      pfam01391
      Location:45102
      Collagen; Collagen triple helix repeat (20 copies)
      pfam09006
      Location:223267
      Surfac_D-trimer; Lung surfactant protein D coiled-coil trimerization

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      40894169..40907155 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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